UW Neurological Surgery Recent PubMed Publications

CONCLUSION/IMPLICATIONS: A person's self-perceived ability to participate and be independent makes a greater contribution to satisfaction with social participation than the frequency of participation. Enhanced understanding of the interplay of subjective and objective factors in influencing participation satisfaction after TBI may result in more effective interventions to support meaningful participation. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

CONCLUSIONS: There was no association between early beta-blocker exposure and the primary outcome which was blood-based brain injury biomarker levels on day 3. In exploratory analysis, we found that early beta-blocker may associated with decreased NSE level on day 14. Due to the retrospective nature of the study and the use of propensity-weighted analysis to identify associations, direct clinical practice changes cannot be recommended. However, the significant association with NSE level warrants...

CONCLUSION: In this multicenter series, the SVB flow diverter represented a valuable treatment option for distal anterior cerebral artery (DACA) aneurysms.

CONCLUSION: This study shows the utility of examining burnout through a psychosocial lens. Further analysis into these relationships could yield actionable interventions that tackle root causes of burnout.

Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a leading contributor to sudden cardiac death worldwide, yet its diagnosis remains complex, expensive and time-consuming. Machine-learning (ML) classifiers offer a practical solution by delivering rapid, scalable predictions that can lessen dependence on expert interpretation and speed clinical decision-making. Here, we benchmarked eight ML algorithms for ARVC detection using area-under-the-curve (AUC) and accuracy as primary metrics....

CONCLUSION: Our study of a multicenter severe TBI cohort did not find a significant difference in 6-month GOSE-TBI between patients monitored with an EVD and those monitored with an IPM. When correcting for other patient characteristics, the selection of ICP monitor type may not affect acute hospital or 6-month functional outcomes.

Accumulating evidence of heterogeneous long-term outcomes after traumatic brain injury (TBI) has challenged longstanding approaches to TBI outcome classification that are largely based on global functioning. A lack of studies with clinical and biomarker data from individuals living with chronic (>1 year post-injury) TBI has precluded refinement of long-term outcome classification ontology. Multimodal data in well-characterized TBI cohorts are required to understand the clinical phenotypes and...

The purpose of this study is to compare payments reported in the Centers for Medicare and Medicaid Services Open Payments Database according to gender. The authors hypothesized that women physicians would have fewer payments and lower total compensation from pharmaceutical and medical device companies as compared with men. A higher proportion of males received > $1,000,000 in compensation from industry, and a higher proportion of females received < $1,000 in compensation from industry. The...

CONCLUSIONS AND RELEVANCE: In this decision analytical model study of approaches to homeless encampments involving individuals with OUD, sweeps increased mortality and spending. Housing without MOUD requirement was the most costly strategy but saved more lives.

CONCLUSION: Individuals with a positive history of smoking are more likely to achieve complete obliteration of grades I-III bAVMs following SRS treatment. However, smokers do not differ from non-smokers in terms of the incidence of post-treatment rupture, overall mortality, or functional status at the last follow-up.

BACKGROUND: Mitral annular disruption is increasingly recognized in our clinical practice and is most commonly due to infective endocarditis or transcatheter or hybrid balloon-expandable mitral valve deployment in the setting of mitral annular calcification.

CONCLUSIONS: Distinct findings between these animal models likely reflect differing alterations in dopamine and noradrenaline neurotransmission that may underlie ADHD-relevant phenotypes.

CONCLUSIONS: CM modifications were not associated with lower levels of alcohol use. Participants engaged in less alcohol use during CM, relative to induction. Two patterns of response to CM were observed based on uEtG-defined heavy drinking immediately prior to CM. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Eukaryotic life evolved over a billion years ago when ancient cells engulfed and integrated prokaryotes to become modern mitochondria and chloroplasts. Sacoglossan "solar-powered" sea slugs possess the ability to acquire organelles within a single lifetime by selectively retaining consumed chloroplasts that remain photosynthetically active for nearly a year. The mechanism for this "animal photosynthesis" remains unknown. Here, we discovered that foreign chloroplasts are housed within novel,...

CONCLUSIONS: Currently, several microleakage assessment techniques are being used, with the dye method being the most reported one. Several variations in the experimental protocols exist, which make it difficult to compare the results. The use of dyes and nuclear medicine methods is sensitive and can be used to evaluate microleakage.

This note reflects on the accomplishments and teachings of Bernie Maskit. Bernie was an expert problem solver, an incredible teacher, and a person who built bridges to faraway lands that connected different people, cultures, and ideas.

Excessive Wnt signaling contributes to the development of fibrotic diseases and cancer. Here, we report the findings of a phase 1 study evaluating AZD5055, an orally administered porcupine inhibitor, which inhibits Wnt signaling. The primary objective was to evaluate the safety and tolerability of AZD5055 in healthy volunteers. Secondary and exploratory objectives were the pharmacokinetics and pharmacodynamics of AZD5055, respectively. Sixty healthy volunteers were randomized to receive placebo...

BackgroundThe effectiveness of endovascular thrombectomy (EVT) for low Alberta Stroke Program Early CT score (ASPECTS) stroke patients with occlusion of the second segment of the middle cerebral artery (M2) is unclear.MethodsThis was a multicenter retrospective study. Patients with M1 or M2 occlusions and low ASPECTS (<6) who underwent successful EVT (modified treatment in cerebral ischemia score of 2b or higher) were included. Primary outcome was futile EVT reperfusion (defined as 90-day...

Energy storage technologies such as lithium-ion batteries (LIBs) incorporate carbon components key to their function. Graphite and carbon binder components in LIB electrodes are engineered to deliver critical electrical and mechanical properties, as are the surface chemistry and morphology of carbon blacks (CBs) in LIBs and catalysts. The challenge of relating surface chemistry to morphology is complicated by the numerous forms of carbon bonding and potential for surface functional groups....

Despite advances in the management of traumatic brain injury (TBI) in the intensive care unit (ICU), and the implementation of new diagnostic techniques and monitoring modalities, the rate of poor neurological outcomes remains high. Specialized neurocritical care units have been shown to improve outcomes. Guidelines have been developed, but most recommendations are based on low levels of evidence. This has led to substantial heterogeneity in clinical practice for many aspects of TBI management,...