UW Neurological Surgery Recent PubMed Publications

CONCLUSIONS: Full-endoscopic lumbar decompression was associated with significantly smaller postoperative increases in CK-MM and myoglobin levels compared with open microscopic surgery, indicating reduced paraspinal muscle injury with the endoscopic approach. Consistent with these biochemical findings, immediate postoperative back pain was also significantly lower in the endoscopic group, further supporting the clinical relevance of reduced paraspinal muscle trauma.

CONCLUSIONS: MRI-based segmentation accurately identified foraminal anatomy that required foraminoplasty for access. This workflow turns a subjective intraoperative judgment into a reproducible, patient-specific geometrical assessment.

CONCLUSIONS: Patients with severe ACLF who underwent LT showed markedly better survival outcomes than those who were declined. Patients with five or six organ failures had high risk of post-LT death cautioning against routine LT in this population.

Cardiomyocyte maturation spans embryogenesis through postnatal life and involves coordinated transcriptional transitions that are disrupted in disease and incompletely recapitulated by stem cell-derived cardiomyocytes. However, no unified framework exists for assigning absolute transcriptional maturation age across datasets, platforms, and experimental conditions. Here, we developed CMAC (Cardiomyocyte Maturation Age Clock), integrating 18 murine single-cell RNA-sequencing datasets spanning...

The COVID-19 pandemic and pandemic response may have long-term consequences. The cumulative impact may be better appraised when post-pandemic years are also considered. For 38 populations with reliable death registration data, we estimated excess deaths for 2020-2025 with granular age stratification. One model (Fa) compared deaths against the mean of 2017-2019. Three other trend models considered changes in mortality rates after 2003 (or after a country reached $20,000 per capita income)...

CONCLUSIONS: By converting routinely preserved pathology sections into integrated regulatory and copy-number profiles, FFPE-CUTAC provides a practical foundation for constructing clinically annotated disease maps to support molecular stratification, prognostic modeling and treatment-association studies.

Aberrant reactivation of embryonic patterning programs is a hallmark of cancer. We previously identified HOXD12 activation in aggressive oligodendrogliomas, but its broader significance across brain tumors remains unexamined. Here, we evaluated HOXD12 protein expression via immunohistochemistry in 162 primary CNS tumors and 84 brain metastases. HOXD12 expression was significantly enriched in primary CNS tumors over brain metastases (P < .0001). Among primary malignancies, medulloblastoma...

No abstract

The instability of mRNA-lipid nanoparticles (LNPs) necessitates ultra-cold storage, limiting global distribution and their broader application in advanced delivery systems. Solid-state, water-free formulations enhance thermostability and enable integration into emerging delivery modalities such as microneedle patches. Previous efforts to stabilize mRNA-LNPs have been constrained by narrow formulation scope and low-throughput screening methods. Here we introduce Algorithm-Guided Experimental...

CONCLUSION: The MRA-based prevalence of UIAs was approximately 9%. The FASH-D model may help identify individuals with a higher probability of having a prevalent UIA, but external validation is required.

CONCLUSIONS: Although baseline overall health status was similar, patients with type 2 MI experienced smaller improvements in health status and reported a greater burden of frailty and impaired physical function over 4 months. These findings highlight the need to address health status domains beyond angina after type 2 MI.

CONCLUSION: In patients undergoing single-session MMAE with surgical evacuation for cSDH, liquid and particle embolic agents demonstrated comparable safety and functional and radiographic efficacy. However, liquid embolization was associated with significantly fewer reinterventions. Adjunctive coiling lengthened procedural time without differences in clinical or radiographic outcomes. Prospective comparative studies are needed to further define the role of embolic material and technical factors...

PURPOSE OF REVIEW: Endoscopic spine surgery has evolved from non-visualized percutaneous discectomy only, into a comprehensive minimally invasive surgical platform with expanding indications across cervical, thoracic, and lumbar pathology. This review examines endoscopic spine surgery's historical evolution, summarizes recent advances in technology and clinical application, and evaluates current evidence regarding outcomes, complications, and future directions.

OBJECTIVE: Sudden Unexpected Death in Epilepsy (SUDEP) is the leading cause of epilepsy-related mortality, particularly in individuals with Developmental and Epileptic Encephalopathies (DEEs). The goal of this work is to assess SUDEP-related knowledge, information practices, emotional and psychological impact, and the use of preventive measures among caregivers of individuals with DEEs across different countries.

No abstract

INTRODUCTION: Respiratory syncytial virus A (RSVA) and respiratory syncytial virus B (RSVB) may induce distinct airway host responses. We compared them with influenza A virus (IAV) and human metapneumovirus (hMPV) in airway organ tissue equivalents (OTEs) and developed the Relaxed Magnitude Altitude Score with Hub-Centric Network Analysis framework (RMAS-HCNA).

Post-pandemic mortality rates can explore the residual COVID-19 burden and changes in other causes of death. Considering weighted multiple causes of death from death certificates (underlying and others) may help compare post- versus pre-pandemic mortality patterns, while potentially reducing the impact of cause misattribution. Estimates of post-pandemic impact are critical also for proper continuing public health policies (e.g. vaccinations). We retrospectively analyse national all-cause...

With smart gadgets and computers everywhere, real-time video monitoring is now necessary to keep people secure and lower the chance of unexpected human actions. However, current surveillance systems have a lot of trouble effectively spotting unusual actions in real life. Most of the advanced anomaly detection algorithms are trained and tested on synthetic or simulated video datasets. These datasets frequently do not show how complicated and different real-life settings can be. Because of this,...

CONCLUSIONS: Clinicians self-reported lower CR referral frequency after type 2 MI than after type 1 MI, with lower perceived benefit and barriers related to CR eligibility and referral process familiarity. Most patients with type 2 MI perceive CR as beneficial and report hypothetical willingness to participate if referred.

CONCLUSION: PCF was beneficial in the cohort overall without producing segmental instability or increasing complexity of necessary larger revision surgeries. PCF should be considered to address persistent or recurrent symptoms in patients with prior CDA.