UW Neurological Surgery Recent PubMed Publications

CONCLUSIONS: Our findings suggest that current methods of clinical identification of B-ICP episodes may not reliably distinguish true episodes of sustained ICP for the most common B-ICP episode type. We suggest developing open-source, real-time, temporally synchronized electronic B-ICP episode definition methods to direct future treatment and research.

Ceramide, a central hub in sphingolipid metabolism, serves as a critical bioactive signalling mediator that integrates lipid metabolism with multiple signalling pathways, primarily promoting autophagy and apoptosis. It influences female reproductive homeostasis and pathophysiology through multiple dimensions: altered ceramide levels have been observed in various reproductive disorders-such as polycystic ovary syndrome (PCOS), premature ovarian insufficiency (POI) and endometriosis (EM)-as well...

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Acquired hemophilia A is a rare autoimmune bleeding disorder caused by neutralizing autoantibodies against factor VIII. It typically affects older adults and may present with spontaneous mucocutaneous bleeding, extensive ecchymoses, soft-tissue hematomas, and isolated prolongation of the activated partial thromboplastin time. We report the case of an 84-year-old woman with hypertension, hyperlipidemia, and anxiety who presented with several weeks of spontaneous nontraumatic bruising, fatigue,...

CONCLUSION: BA reduced early postoperative moderate-to-severe CRBD and rescue medication use after URSL. BA may be a safe, non-pharmacological adjunct for acute postoperative CRBD management.

CONCLUSION: ECA-to-V3 VA bypass with atlantoaxial decompression is a safe and effective surgical option for patients with medically refractory VBI, offering durable symptom control and a low risk of neurological complications. Although postoperative neck discomfort is not uncommon, the overall safety profile and efficacy of the procedure support its consideration in carefully selected patients.

Messenger RNA lipid nanoparticles are promising vaccine carriers, yet their movement through the body after intramuscular injection and the resulting tissue-specific immune effects remain poorly defined. Here we show that lipid nanoparticle trafficking from the injection site into systemic organs is a key determinant of localized immunity, particularly the formation of tissue-resident cytotoxic T cells. We compared multiple nanoparticle formulations that differed in lipid composition, including...

CONCLUSIONS: In this large multicenter cohort, MMAE was associated with a 5.1% complication rate. Technical success was the strongest protective factor. Embolization with or without surgery showed equivalent safety profiles.

Brain aneurysms are a cerebrovascular disease that results in a severe type of stroke. The cell-specific molecular pathology underlying their formation and rupture is unknown. Here we profile 227,663 neurovascular cells, including 52,946 aneurysmal cells, from a total of 14 adult human brain aneurysms and 11 control vessels. Our atlas of human brain aneurysms, as well as cell-resolution spatial transcriptomics, revealed that pathological cerebrovascular remodeling occurs with the loss of...

INTRODUCTION: Obesity arises from the interplay between genetic predisposition, metabolic signaling, and neural circuits that regulate feeding and energy expenditure. Large-scale association studies repeatedly implicate regulators of Ras/Rap GTPase signaling in adiposity and metabolic risk, but the mechanisms linking these intracellular switch modules to neural control of energy balance remain unclear.

Generalizable neuroimaging biomarkers that detect cerebral cortical changes after traumatic brain injury (TBI) and predict patient outcomes are needed to improve care and to develop targeted therapies. We used morphometric inverse divergence (MIND) analysis of structural MRI to investigate cortical gray matter morphological networks cross-sectionally and longitudinally after TBI and correlate these with symptoms, disability and cognition six months after injury. Our findings support the Triple...

CONCLUSION: These findings suggest that HMP-C usage is related to reductions in perceived stress and robust to potential usage barriers. Future research is needed to identify the optimal dose of DHI mindfulness, which balances feasibility and targeted outcomes.

Previous research has shown that immune development during the first week of life, i.e. ontogeny, is progressive, consistent and robust, involving large numbers of differentially expressed genes at each sampled time point. To obtain more granular detail about conserved and population-specific ontogeny, the influence of day of life on blood gene expression and cell type composition was examined in two distinct neonatal populations, from The Gambia and Papua New Guinea, employing block...

Endoscopic retrograde cholangiopancreatography (ERCP) is a widely used therapeutic procedure for pancreatobiliary disorders but is associated with a range of complications, most commonly post-ERCP pancreatitis (PEP). Post-ERCP air leak syndromes-including pneumothorax, pneumomediastinum, pneumoperitoneum, and subcutaneous emphysema-are exceptionally rare, particularly in the absence of an identifiable gastrointestinal perforation. We report the case of a 72-year-old woman who developed severe...

The notorious Queen vs Dudley and Stephens case highlights the persistent potential conflict between safeguarding individual rights and serving the collective good, a dilemma that also arises in clinical research. Doctors face the challenge of providing the best possible care for each patient while contributing to medical progress through randomized clinical trials. A key concept is equipoise: Fried emphasized personal uncertainty, whereas Freedman proposed clinical equipoise, grounded in...

CONCLUSIONS: The data reveal a role for microenvironment Cav3 in promoting GBM progression through regulating neuronal and glial processes. Targeting both intrinsic and microenvironment Cav3 with the inhibitor mibefradil significantly enhanced the anti-GBM effects of TMZ and radiation.

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CONCLUSION: In this cross-sectional analysis, aspirin use was independently associated with reduced AWE in patients with UIAs, while statin use was not. However, the cross-sectional design precludes causal inference regarding a direct anti-inflammatory effect on the aneurysm wall.

CONCLUSIONS: The percentage of participants with surgical complications did not differ significantly between those who underwent PFD-D and and those who underwent PFD alone. Larger trials are needed to determine the relative benefits and risks of these two procedures. (Funded by the Patient-Centered Outcomes Research Institute and others; ClinicalTrials.gov number, NCT02669836.).

CONCLUSIONS: Overall, these studies indicate that prime-and-HDT trap vaccination offers a tractable new strategy to study immunity to liver stage malaria in mice that is inexpensive, reproducible, and accessible.