UW Neurological Surgery Recent PubMed Publications

CONCLUSIONS: The bifrontal interhemispheric approach offers the ability to expose large and giant ACoA aneurysms and bilateral A2 vessel aneurysms, which allows an operative corridor for possible bypass revascularization. The results of this approach were excellent, with a low rate of aneurysm recurrence and complications.

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Algae, including both eukaryotes and prokaryotes (cyanobacteria), play a crucial role in aquatic ecosystems. However, eutrophication caused by human activities has led to excessive algal blooms, degrading water quality. Traditional phytoplankton monitoring methods are limited in scale and cost, whereas remote sensing emerges as an efficient alternative, enabling broad and continuous analysis. Chlorophyll-a, a pigment found in algae and cyanobacteria, is a key indicator of phytoplankton biomass...

CONCLUSIONS: In this pilot study, quantitative smartphone pupillometry demonstrates the potential to be a useful tool in the future diagnosis of acute mTBI.

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Rett Syndrome is a rare, x-linked genetic neurological disorder caused by MECP2 gene mutations. This progressive neurodevelopmental disorder hinders patients' ability to breathe and eat normally. It is unclear how Mecp2- deficiency results in a high percentage of dysphagia and aspiration pneumonia in patients with Rett syndrome. We aim to determine the effects of Mecp2 -deficiency on swallow related neuromuscular mechanisms contributing to dysphagia in Rett syndrome. Swallow and breathing were...

INTRODUCTION: Colorectal cancer (CRC) screening rates among patients receiving care at multiple federally qualified health care centers (FQHCs) in New York city are low. Proactive outreach through mailed fecal immunochemical tests (FIT), reminders and navigation are evidence based interventions to improve CRC screening rates but remain untested in this study population.

CONCLUSIONS: In patients undergoing resection of growth hormone-secreting tumor for treatment of acromegaly, microscopic invasion of tissues is relatively common and portends an increased risk of failure of surgical biochemical remission. Identification of microscopic invasion may allow for more aggressive surgical management and better chances of surgical control of disease.

CONCLUSIONS: In adults presenting to Level I trauma centers for acute mTBI, symptom burden (RPQ total score) is robustly associated with 3-month symptom outcome. The RPQ, which can be completed in about 3 min, may support recognition of mTBI symptoms in the ED and risk stratification for triage into appropriate follow-up pathways.

CONCLUSIONS: Results indicate role strain experienced by OB nursing students, regardless of gender identification, continues to be a significant factor in the current clinical environment. Educators can utilize this awareness of increasing role strain in the context of sociocultural influence among students in the OB clinical setting to improve the student experience.

CONCLUSIONS: Our multisite study showed that neuroradiologists performed better than AI for IA detection in terms of sensitivity and accuracy, while while achieving comparable specificity.

CONCLUSIONS: While surgical care provided favorable short-term functional outcomes, long-term survival for children with pLGGs in Kenya remains substantially low. These findings call for urgent development of robust pediatric neuro-oncology multidisciplinary care and structured long-term follow-up pathways.

CONCLUSION: These simple, practical, cost-effective tools have utility for estimating preoperative fitness to rule out low fitness. These tools could be utilised by perioperative clinicians for identifying patients who may not require preoperative cardiopulmonary exercise testing, thereby optimising resource allocation.

No abstract

CONCLUSIONS: Primary care clinics that implement office-based addiction treatment by nurses increase patient-years of opioid use disorder (OUD) treatment in male but not female patients. Exploratory findings suggest that differences in the proportion of patients treated for OUD, rather than differences in the duration of OUD treatment, account for observed differences across groups.

Somatosensory perception largely emerges from diverse peripheral sensory neurons whose cell bodies reside in dorsal root ganglia (DRG). Damage or dysfunction of DRG neurons is a major cause of chronic pain and sensory loss. In mice, deep single-cell transcriptomic profiling and genetically defined models have offered important clues into DRG function, but in humans, the cellular and molecular landscape of DRG neurons remains less understood. Here, we constructed a reference cell atlas of the...

The ribosome is the highly conserved molecular machine that decodes mRNAs during protein synthesis. While traditionally thought to consist of a uniform set of proteins, here we discover that ribosome composition is reprogrammed to adapt to intrinsic and external cellular perturbations. During infection by non-segmented negative-sense viruses, viral entry into cells recruits the large ribosomal subunit protein rpL40 to a noncanonical site on the small subunit of 80S ribosomes near the mRNA entry...

Glioblastoma (GBM) quiescent (Q) cell populations are hypothesized to contain cancer stem-like cells (CSC) that drive tumor growth, cellular heterogeneity, and recurrence. However, GBM tumors do not neatly resolve into developmental hierarchies and Q stem-like activities are difficult to assess. Here, we evaluated tumor Q subpopulations in patient-derived GBM xenograft tumors using live cell reporters, DNA label retention assays, and single cell genomics. Compared to adult neural stems cells...

Cognitive decline with aging, and some neurodegenerative conditions like Alzheimer's disease, disproportionately affects females yet few mechanisms beyond steroid hormone signaling fully explain this sex-specific vulnerability. The chromatin-remodeling DEK protein, upregulated by estrogen and progesterone and broadly expressed in the brain, including the hippocampus, may be one such mechanism. We have previously linked DEK loss with indices of neuronal dysfunction, including increased DNA...

Alzheimer's disease (AD) is the most common cause of dementia, with global case numbers projected to reach 153 million in 2050 ¹ . AD is highly heritable, with twin-based heritability estimates of 60-80% ² . While 1,200 causal loci are predicted to exist for AD ³ , approximately 80 have been associated with AD in two recent studies ^(4,5) , suggesting that many loci remain to be discovered ⁶ . Here, we analyzed data from 183,620 AD cases and 2.6 million controls from diverse ancestries,...