UW Neurological Surgery Recent PubMed Publications

Neuronal-cancer cell interactions are a key component of brain tumor pathophysiology, yet many fundamental questions remain unanswered - with even more remaining unasked. Here, we present a comprehensive brain tumor reference map generated from bulk RNA-seq data of ∼4,300 adult and pediatric brain tumors-including various glioma subtypes, medulloblastomas, ependymomas, and meningiomas-alongside ∼1,400 healthy brain samples. By analyzing synaptic processes and synaptic gene expression across...

We describe the evolution of our early hit-identification workflow for reagent-mediated amidation reactions in support of commercial route development. Over the past decade, our strategy progressed from broad, exhaustive high-throughput experimentation (HTE) with limited data maturity to a modern, enterprise-scale digital platform that embeds data science tools directly into the experimental workflow. By tailoring Katalyst D2Da commercial electronic laboratory notebook (ELN) for HTE developed...

CONCLUSION: Together, these findings identify FA pathway components as key synthetic lethal interactors of CCNU response and reveal a therapeutically actionable vulnerability in glioblastoma.

Reducing dietary potassium (K) and phosphorus (P) intake is considered a cornerstone for managing hyperkalemia and hyperphosphatemia in adults with chronic kidney disease (CKD). K and P additives in processed foods are a growing concern as hidden sources of these minerals, yet their prevalence is unknown. The objective of this study was to investigate the characteristics of foods purchased by individuals with CKD, including the prevalence and types of K and P additives and the food categories...

The ribosome is the highly conserved molecular machine that decodes mRNAs during protein synthesis. Here, we discover that, while traditionally thought to consist of a uniform set of proteins, ribosome composition is reprogrammed to adapt to intrinsic and external cellular perturbations. During infection of human cells by non-segmented negative-sense viruses, viral entry into cells recruits the large ribosomal subunit protein rpL40 to a non-canonical site on the small subunit of 80S ribosomes...

Limiting the expansion of the primary injury after a traumatic spinal cord injury (SCI) can offer improved functional outcomes. Glibenclamide (glyburide) has been shown to limit intraspinal bleeding and promote vascular stability after SCI in rats, but its impact on intraspinal hemodynamics has not been investigated. Here, we hypothesized that acute glibenclamide treatment would improve intraspinal hemodynamics after a cervical contusion SCI in a rat model (200 kdyn). Intravital ultrafast...

In rectifying power electronics, wider-bandgap (E(g)) semiconductors allow higher efficiency and power density with the Baliga figure of merit proportional to E(g)^(5.5) (refs. ^(1,2)). Unfortunately, the unique ability of semiconductors to have their conductivities controllably modulated over orders of magnitude by equilibrium doping methods becomes increasingly elusive as the bandgap increases. Increasing demand for wider-bandgap semiconductors has led to many materials previously considered...

CONCLUSION: Use of IHC for identification of lineage specific TF markedly improves the accuracy of correct pathological diagnosis of NF PitNETs.

Most proteins start to fold cotranslationally as they come off the ribosome. So far, studies of cotranslational folding have focused mainly on small, single-domain proteins. Here, we have used Force Profile Analysis to study the cotranslational folding of Firefly Luciferase, a complex 550-residue protein composed of an N-terminal domain (NTD) encompassing two split Rossmann folds (RF-1, RF-2) and a β-roll, and a flexibly attached C-terminal domain (CTD). The folding process is characterized by a...

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CONCLUSIONS: Endoscopic lumbar decompression improves pain and disability, whereas mobility gains are modest and dependent on baseline function. Lower baseline function predicts greater improvement, whereas early postoperative increases in walking are strongly associated with satisfaction. These findings highlight the importance of setting realistic expectations with patients regarding postoperative functional recovery, while emphasizing the need for future studies to test whether structured...

CONCLUSIONS: The authors conducted a retrospective review of a large, multicenter cohort, demonstrating similar outcomes between primary and revision thoracolumbar endoscopic decompression and discectomies, as measured by the ODI and an MCID in the ODI.

CONCLUSIONS: SPINEHealthie closes a key visibility gap in the early postoperative course after ambulatory endoscopic spine surgery by enabling remote, high-frequency measurement integrated with active care delivery. Conventional registries optimize for long-term benchmarking after traditional spine procedures; SPINEHealthie optimizes for ultra-early outpatient recovery surveillance after tissue-sparing surgery. These findings demonstrate that purpose-built digital registries can meaningfully...

CONCLUSIONS: Full-endoscopic lumbar decompression was associated with significantly smaller postoperative increases in CK-MM and myoglobin levels compared with open microscopic surgery, indicating reduced paraspinal muscle injury with the endoscopic approach. Consistent with these biochemical findings, immediate postoperative back pain was also significantly lower in the endoscopic group, further supporting the clinical relevance of reduced paraspinal muscle trauma.

CONCLUSIONS: MRI-based segmentation accurately identified foraminal anatomy that required foraminoplasty for access. This workflow turns a subjective intraoperative judgment into a reproducible, patient-specific geometrical assessment.

CONCLUSIONS: Patients with severe ACLF who underwent LT showed markedly better survival outcomes than those who were declined. Patients with five or six organ failures had high risk of post-LT death cautioning against routine LT in this population.

Cardiomyocyte maturation spans embryogenesis through postnatal life and involves coordinated transcriptional transitions that are disrupted in disease and incompletely recapitulated by stem cell-derived cardiomyocytes. However, no unified framework exists for assigning absolute transcriptional maturation age across datasets, platforms, and experimental conditions. Here, we developed CMAC (Cardiomyocyte Maturation Age Clock), integrating 18 murine single-cell RNA-sequencing datasets spanning...

The COVID-19 pandemic and pandemic response may have long-term consequences. The cumulative impact may be better appraised when post-pandemic years are also considered. For 38 populations with reliable death registration data, we estimated excess deaths for 2020-2025 with granular age stratification. One model (Fa) compared deaths against the mean of 2017-2019. Three other trend models considered changes in mortality rates after 2003 (or after a country reached $20,000 per capita income)...

CONCLUSIONS: By converting routinely preserved pathology sections into integrated regulatory and copy-number profiles, FFPE-CUTAC provides a practical foundation for constructing clinically annotated disease maps to support molecular stratification, prognostic modeling and treatment-association studies.