1 year 6 months ago
CONCLUSION: Naloxone distribution volumes were correlated with fatal opioid overdose, suggesting medication was getting to communities where it was needed most. Amid high rates of overdose driven by fentanyl in the drug supply, our findings suggest additional prevention, treatment, and harm reduction interventions are required-and dramatically higher naloxone volumes needed-to reverse the opioid overdose crisis in the US.
Jake R Morgan
1 year 6 months ago
Response resistance to the immune checkpoint blockade (ICB) immunotherapy remains a major clinical challenge that may be overcome through the rational combination of ICB and specific targeted therapeutics. One emerging combination strategy is based on sensitizing ICB-refractory tumors with antagonists of 90kD heat shock protein (Hsp90) that target all four isoforms. However, pan-Hsp90 inhibitors are limited by the modest efficacy, on-target and off-tumor toxicities, and induction of the heat...
Sharif Rahmy
1 year 6 months ago
Wildlife species are often used as bioindicators to evaluate the extent and severity of environmental contamination and the effectiveness of remediation practices. A common approach for investigating population- or community-level impacts on bioindicators compares demographic parameter estimates (e.g., population size or density) between sites that were subjected to different levels of contamination. However, the traditional analytical method used in such studies is nonspatial capture-recapture,...
Sean M Murphy
1 year 6 months ago
Whole-sporozoite (WSp) malaria vaccines induce protective immune responses in animal malaria models and in humans. A recent clinical trial with a WSp vaccine comprising genetically attenuated parasites (GAP) which arrest growth early in the liver (PfSPZ-GA1), showed that GAPs can be safely administered to humans and immunogenicity is comparable to radiation-attenuated PfSPZ Vaccine. GAPs that arrest late in the liver stage (LA-GAP) have potential for increased potency as shown in rodent malaria...
Blandine Franke-Fayard
1 year 6 months ago
No abstract
Guillaume Butler-Laporte
1 year 6 months ago
No abstract
Gema Maria Lledó-Ibáñez
1 year 6 months ago
No abstract
Melanie Dostert
1 year 6 months ago
No abstract
Khiry Sutton
1 year 6 months ago
No abstract
Shayla Nolen
1 year 6 months ago
No abstract
Tabitha R F Green
1 year 6 months ago
No abstract
Sungwoo Lim
1 year 7 months ago
No abstract
Oula Khoury
1 year 7 months ago
No abstract
Som Dev
1 year 7 months ago
No abstract
Nicholas A Vitanza
1 year 7 months ago
No abstract
Nakeya Dewaswala
1 year 7 months ago
No abstract
Tabitha R F Green
1 year 7 months ago
No abstract
Sean M Barber
1 year 7 months ago
Salmonella is an intracellular pathogen causing significant morbidity and mortality. Its ability to grow inside macrophages is important to virulence, and is dependent on the activation state of the macrophages. Classically activated M1 macrophages are non-permissive for Salmonella growth, while alternatively activated M2 macrophages are permissive for Salmonella growth. Here we showed that endotoxin-primed macrophages (MEP), such as those associated with sepsis, showed similar levels of...
Katharine Sedivy-Haley
1 year 7 months ago
CONCLUSIONS: Current evidence on comparative outcomes of RMVS and CSMVS is limited with only low-quality studies currently available. This present meta-analysis suggests that RMVS may have lower mortality and shorter ICU and hospital LOS, however CSMVS may be associated with significantly shorter cross clamp and CPB times. Further analysis of high-quality studies with randomized data is required to verify these results.
Michael L Williams
1 year 7 months ago
CONCLUSION: This is the first large-scale study to suggest that daily volume of specific suicide-prevention-related social media content on Twitter corresponds to higher daily levels of help-seeking behaviour and lower daily number of suicide deaths.
Thomas Niederkrotenthaler
"university of washington"[affiliation] and neurological surge...: Latest results from PubMed
More posts about UW Neurological Surgery Recent PubMed Publications