UW Neurological Surgery Recent PubMed Publications

Single-Session Middle Meningeal Artery Embolization With Concomitant Evacuation Surgery for Chronic Subdural Hematomas: A Multicenter Assessment of Feasibility, Safety, and Efficacy

1 day 2 hours ago
CONCLUSION: Single-session MMAE with concomitant surgical evacuation proved feasible and safe. Radiographic and clinical outcomes were favorable, without higher complication rates compared with staged approaches. Future prospective studies should clarify the long-term benefits, assess the impact on resource use and cost-minimization, and determine ideal patient-selection criteria for this integrated treatment strategy.
Santiago Gomez-Paz

Dimensions of participation as predictors of satisfaction with roles and abilities after traumatic brain injury

1 day 2 hours ago
CONCLUSION/IMPLICATIONS: A person's self-perceived ability to participate and be independent makes a greater contribution to satisfaction with social participation than the frequency of participation. Enhanced understanding of the interplay of subjective and objective factors in influencing participation satisfaction after TBI may result in more effective interventions to support meaningful participation. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
Amanda M Wisinger

Early beta-blocker exposure and association with brain injury biomarkers following moderate to severe traumatic brain injury: A TRACK-TBI study

2 days 2 hours ago
CONCLUSIONS: There was no association between early beta-blocker exposure and the primary outcome which was blood-based brain injury biomarker levels on day 3. In exploratory analysis, we found that early beta-blocker may associated with decreased NSE level on day 14. Due to the retrospective nature of the study and the use of propensity-weighted analysis to identify associations, direct clinical practice changes cannot be recommended. However, the significant association with NSE level warrants...
Pattrapun Wongsripuemtet

Machine Learning Models Enhance Prediction of Arrhythmogenic Right Ventricular Cardiomyopathy

4 days 2 hours ago
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a leading contributor to sudden cardiac death worldwide, yet its diagnosis remains complex, expensive and time-consuming. Machine-learning (ML) classifiers offer a practical solution by delivering rapid, scalable predictions that can lessen dependence on expert interpretation and speed clinical decision-making. Here, we benchmarked eight ML algorithms for ARVC detection using area-under-the-curve (AUC) and accuracy as primary metrics....
Kwaku K Quansah

External Ventricular Drain Versus Intraparenchymal Pressure Monitor in Severe Traumatic Brain Injury: A TRACK-TBI Study

4 days 2 hours ago
CONCLUSION: Our study of a multicenter severe TBI cohort did not find a significant difference in 6-month GOSE-TBI between patients monitored with an EVD and those monitored with an IPM. When correcting for other patient characteristics, the selection of ICP monitor type may not affect acute hospital or 6-month functional outcomes.
Madeline E Greil

Distinct clinical phenotypes and their neuroanatomic correlates in chronic traumatic brain injury

1 week ago
Accumulating evidence of heterogeneous long-term outcomes after traumatic brain injury (TBI) has challenged longstanding approaches to TBI outcome classification that are largely based on global functioning. A lack of studies with clinical and biomarker data from individuals living with chronic (>1 year post-injury) TBI has precluded refinement of long-term outcome classification ontology. Multimodal data in well-characterized TBI cohorts are required to understand the clinical phenotypes and...
Raj G Kumar

Shedding Sunshine on Gender Inequities in Industry Compensation to Physicians: a Centers for Medicare and Medicaid Services Open Payment Analysis

1 week ago
The purpose of this study is to compare payments reported in the Centers for Medicare and Medicaid Services Open Payments Database according to gender. The authors hypothesized that women physicians would have fewer payments and lower total compensation from pharmaceutical and medical device companies as compared with men. A higher proportion of males received > $1,000,000 in compensation from industry, and a higher proportion of females received < $1,000 in compensation from industry. The...
Adam M Almaguer

Impact of smoking on occlusion rates following stereotactic radiosurgery for Spetzler Martin grade I-III brain arteriovenous malformations - A propensity score matched analysis of the MISTA consortium

1 week ago
CONCLUSION: Individuals with a positive history of smoking are more likely to achieve complete obliteration of grades I-III bAVMs following SRS treatment. However, smokers do not differ from non-smokers in terms of the incidence of post-treatment rupture, overall mortality, or functional status at the last follow-up.
Daniel Sconzo

Testing adaptations to contingency management for alcohol use disorders: A randomized controlled trial

1 week 1 day ago
CONCLUSIONS: CM modifications were not associated with lower levels of alcohol use. Participants engaged in less alcohol use during CM, relative to induction. Two patterns of response to CM were observed based on uEtG-defined heavy drinking immediately prior to CM. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
Michael G McDonell

A host organelle integrates stolen chloroplasts for animal photosynthesis

1 week 1 day ago
Eukaryotic life evolved over a billion years ago when ancient cells engulfed and integrated prokaryotes to become modern mitochondria and chloroplasts. Sacoglossan "solar-powered" sea slugs possess the ability to acquire organelles within a single lifetime by selectively retaining consumed chloroplasts that remain photosynthetically active for nearly a year. The mechanism for this "animal photosynthesis" remains unknown. Here, we discovered that foreign chloroplasts are housed within novel,...
Corey A H Allard

In Vitro Techniques for Microleakage Evaluation of Coronary Restorative Materials: A Scoping and Mapping Review

1 week 2 days ago
CONCLUSIONS: Currently, several microleakage assessment techniques are being used, with the dye method being the most reported one. Several variations in the experimental protocols exist, which make it difficult to compare the results. The use of dyes and nuclear medicine methods is sensitive and can be used to evaluate microleakage.
Sofia Vieira

A phase 1 study evaluating the safety, tolerability, and pharmacokinetics of the porcupine inhibitor, AZD5055

2 weeks ago
Excessive Wnt signaling contributes to the development of fibrotic diseases and cancer. Here, we report the findings of a phase 1 study evaluating AZD5055, an orally administered porcupine inhibitor, which inhibits Wnt signaling. The primary objective was to evaluate the safety and tolerability of AZD5055 in healthy volunteers. Secondary and exploratory objectives were the pharmacokinetics and pharmacodynamics of AZD5055, respectively. Sixty healthy volunteers were randomized to receive placebo...
Xiao-Hong Zhou

Treatment outcomes of successful M1 versus M2 thrombectomy for low-ASPECTS stroke patients

2 weeks 2 days ago
BackgroundThe effectiveness of endovascular thrombectomy (EVT) for low Alberta Stroke Program Early CT score (ASPECTS) stroke patients with occlusion of the second segment of the middle cerebral artery (M2) is unclear.MethodsThis was a multicenter retrospective study. Patients with M1 or M2 occlusions and low ASPECTS (<6) who underwent successful EVT (modified treatment in cerebral ischemia score of 2b or higher) were included. Primary outcome was futile EVT reperfusion (defined as 90-day...
Huanwen Chen

Secondary Electron Hyperspectral Imaging of Carbons: New Insights and Good Practice Guide

2 weeks 3 days ago
Energy storage technologies such as lithium-ion batteries (LIBs) incorporate carbon components key to their function. Graphite and carbon binder components in LIB electrodes are engineered to deliver critical electrical and mechanical properties, as are the surface chemistry and morphology of carbon blacks (CBs) in LIBs and catalysts. The challenge of relating surface chemistry to morphology is complicated by the numerous forms of carbon bonding and potential for surface functional groups....
James F Nohl
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