I have a long-standing interest in DNA-repair-mediated resistance to alkylating agents and radiation in human brain tumors, and have directed a number of translationally relevant projects that investigate strategies to circumvent resistance. I have broad training and experience in DNA repair, radiobiology and DNA replication, and a long history of directing NIH- and foundation-funded grants key research areas for our proposal.
Dr. Silbergeld is the Arthur A. Ward Jr. professor of neurological surgery and is based at the UW Medical Center. He is also an adjunct professor of pathology. He specializes in tumors of the central nervous system, pituitary tumors, epilepsy surgery and radiosurgery with the Gamma Knife. He is board certified in neurological surgery.
His research program focuses on gliomas, a type of brain tumor, and on methods to break the blood/brain barrier to deliver chemotherapy to malignant brain tumors.
Dr. Eric Holland earned a doctorate in biochemistry and molecular biology from the University of Chicago and a medical degree from Stanford University. He completed a neurosurgery residency at the University of California at Los Angeles School of Medicine and a fellowship at the National Cancer Institute in Bethesda, Maryland. His postdoctoral training included work with two Nobel laureates: Dr. Paul Berg, who pioneered recombinant DNA technology at Stanford, and Dr. Harold Varmus, director of the National Cancer Institute.
Courtney Crane, PhD, is a principal investigator at Seattle Children's Research Institute's Ben Towne Center for Childhood Cancer Research and an assistant professor at the University of Washington School of Medicine. She received her PhD from the University of Virginia and completed a research fellowship in the department of neurosurgery at the University of California, San Francisco.
For more information about the Crane lab's research and about career opportunities in the lab, email Courtney Crane.