UW Neurological Surgery Recent PubMed Publications

BackgroundWe investigated racial disparities in radiologic and clinical outcomes of patients after middle meningeal artery embolization (MMAE) for chronic subdural hematoma (CSDH) with or without evacuation surgery.MethodsThis multicenter retrospective study includes consecutive patients who underwent MMAE across 11 institutions in North America (10 in the United States and 1 in Canada). Patients were stratified using self-reported racial data. Outcomes of interest were complications, treatment...

BackgroundMiddle meningeal artery embolization (MMAE) is a promising treatment for chronic subdural hematoma (cSDH). Cancer patients are at risk for cSDH due to thrombocytopenia. The efficacy of MMAE in this population has not been studied.MethodsWe conducted a retrospective analysis of 76 patients who underwent 94 MMAEs for cSDH at 12 tertiary centers across North America and Europe between February 2018 and January 2023. We analyzed patient demographics, clinical profiles, procedural details,...

Quiescence cancer stem-like cells may play key roles in promoting tumor cell heterogeneity and recurrence for many tumors, including glioblastoma (GBM). Here we show that the protein acetyltransferase KAT5 is a key regulator of transcriptional, epigenetic, and proliferative heterogeneity impacting transitions into G0-like states in GBM. KAT5 activity suppresses the emergence of quiescent subpopulations with neurodevelopmental progenitor characteristics, while promoting GBM stem-like cell (GSC)...

The objective of this study was to characterize the 24-h blood pressure response following an acute hot-water immersion exposure, specifically examining the effect of immersion duration and water temperature, in people with hypertension. Sixteen participants (11 females; 62 ± 7 y; 31.7 ± 7.5 kg.m^(-2)) with hypertension (taking at least one anti-hypertensive medication) completed four randomized sessions: 1) 20-min and 2) 40-min hot-water immersion (40°C), 3) 40-min thermoneutral immersion...

A subset of long-duration spaceflight astronauts at the International Space Station has been documented to develop spaceflight associated neuro-ocular syndrome (SANS). Researchers have sought to understand SANS by quantification of ocular and brain structural changes thought to be associated with weightlessness induced headward fluid shift. Brain tissue shift and cerebrospinal fluid (CSF) redistribution has been observed as measured by MRI on return to Earth, and not fully quantified. To improve...

Adherence to Pre-Exposure Prophylaxis (PrEP) among young sexual and gender minority men who have sex with men (YSGMMSM) has been suboptimal for reducing HIV incidence in the United States. Using the syndemic framework, the present study characterized how neighborhood disadvantage and clustering of two or more syndemic conditions (depression, anxiety, polysubstance use, history of arrest, BIPOC racial identity, unemployment) was related to PrEP non-adherence among 212 YSGMMSM aged 16-24. This...

CONCLUSIONS: The study underscores the feasibility of FPMSCs for clinical uses under GMP conditions and emphasizes the importance of optimized culture protocols to improve cell proliferation and potency in MSC-based therapies.

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Tumor-infiltrating lymphocyte (TIL) therapy, recently approved by the FDA for melanoma, is an emerging modality for cell-based immunotherapy. However, its application in immunologically "cold" tumors such as glioblastoma remains limited due to sparse T cell infiltration, antigenic heterogeneity, and a suppressive tumor microenvironment. To identify genomic and spatial determinants of TIL expandability, we performed integrated, multimodal profiling of high-grade gliomas using spectral flow...

CONCLUSION: Pre-operative peak VO2 was associated with physical and subjective recovery following total hip or knee arthroplasty. Daily step count and estimated peak VO2 via the DASI questionnaire had similar moderate associations with post-operative functional outcomes as directly measured pre-operative peak VO2 and may be acceptable alternatives to predict recovery following hip or knee arthroplasty.

CONCLUSIONS: Our study provides insight into the scope and value of resources incurred to implement community-based interventions to reduce opioid overdose deaths across four states.

In the United States, the Food Safety and Inspection Service (FSIS), which is part of the U.S. Department of Agriculture, oversees multiple sampling programs that focus on detecting microbial contamination of meat and poultry in slaughter and processing establishments. There have been efforts across scientific disciplines to describe data collection methods and estimation strategies for large scale surveys to allow for the integration of data from multiple sources. The FSIS sample selection...

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Acute decompensated heart failure is a common problem and is frequently associated with diuretic resistance from cardiorenal syndrome. We present the first in human use of the JuxtaFlow Renal Assist Device (RAD) to treat congestion in patients admitted to the hospital with acute decompensated heart failure. In an open-label single-arm trial, patients admitted with acute decompensated heart failure who were diuretic resistant underwent placement of the RAD catheter system and received treatment...

Background Chronic subdural hematoma (cSDH) is a common neurosurgical condition, and middle meningeal artery embolization (MMAE) has emerged as a minimally invasive adjunct to surgery, but optimal timing remains unclear. Purpose To investigate radiographic and clinical outcomes of patients with cSDH undergoing MMAE as an adjunct to surgical evacuation, focusing on order and timing of MMAE relative to surgery. Materials and Methods This multicenter, retrospective study included consecutive...

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YAP1 gene fusions are found in a multitude of human tumors, are potent oncogenic drivers, and are the likely initiating tumorigenic events in these tumors. We and others have previously shown that a YAP1 fusion proteins exert TEAD-dependent oncogenic YAP1 activity that is resistant to inhibitory Hippo pathway signaling. However, the contributions of the C-terminal fusion partners to the oncogenic functions of YAP1 fusion proteins are understudied. Here, we used the RCAS/tv-a system to express...

Dhairya Rajguru was not included as an author in the original publication [...].

CONCLUSION: Single draining vein AVMs were more likely to present with rupture, but no significant differences in obliteration rates, functional outcomes, or retreatment rates were found between the groups after adjustment. These findings suggest that while venous drainage patterns may influence initial presentation, they do not appear to affect overall treatment success or patient prognosis after any treatment type. Further studies are needed to confirm.

What do Australians believe would change their current opinions about climate change? In this study, we used audience segmentation analysis through the Six Americas Short Survey to identify groups of climate opinion holders within a representative sample of Australians. We had 4857 participants tell us what it would take to change their current opinions about climate change and leveraged OpenAI's Generative Pre-Trained Transformer (GPT) to identify the presence or absence of themes (Nothing,...