Daniel L. Silbergeld, M.D.

Portrait of Daniel L. Silbergeld, M.D.
Job Title
Arthur A. Ward Jr. Professor of Neurological Surgery

Dr. Silbergeld is the Arthur A. Ward Jr. professor of neurological surgery and is based at the UW Medical Center. He is also an adjunct professor of pathology. He specializes in tumors of the central nervous system, pituitary tumors, epilepsy surgery and radiosurgery with the Gamma Knife. He is board certified in neurological surgery. 

His research program focuses on gliomas, a type of brain tumor, and on methods to break the blood/brain barrier to deliver chemotherapy to malignant brain tumors.

Clinical Interest

Brain tumors; epilepsy surgery; functional brain mapping for language, movement and sensation; pituitary tumors, gamma knife radiosurgery.

Research Interests

Glioma invasion and motility; the use of high-intensity focused ultrasound to temporarily disrupt the blood-brain barrier to enable delivery of chemotherapeutic agents to brain tumors.

Personal Interests

Fly fishing, working out and spending time with my family.


Medical Education

University of Cincinnati College of Medicine


University of Washington


University of Washington


University of Washington

Board Certification
American Board of Neurological Surgery - 1995
Contact Information






  • Ene CI, Nerva JD, Morton RP, Barkley AS, Barber JK, Ko AL, Silbergeld DL. Safety and efficacy of carmustine (BCNU) wafers for metastatic brain tumors. Surg Neurol Int. 2016;7(Suppl 11):S295-9. Epub 2016/05/25. doi: 10.4103/2152-7806.181987. PubMed PMID: 27217968; PubMed Central PMCID: PMC4866053.
  • Sonabend AM, Zacharia BE, Cloney MB, Sonabend A, Showers C, Ebiana V, Nazarian M, Swanson KR, Baldock A, Brem H, Bruce JN, Butler W, Cahill DP, Carter B, Orringer DA, Roberts DW, Sagher O, Sanai N, Schwartz TH, Silbergeld DL, Sisti MB, Thompson RC, Waziri AE, McKhann G, 2nd. Defining Glioblastoma Resectability Through the Wisdom of the Crowd: A Proof-of-Principle Study. Neurosurgery. 2016. Epub 2016/08/11. doi: 10.1227/NEU.0000000000001374. PubMed PMID: 27509070.
  • Ene CI, Nerva JD, McGrath L, Flanagan ME, Chamberlain MC, Silbergeld DL.  Flow-related aneurysm within glioblastoma: A case report and review of literature. World Neurosurgery. World Neurosurgery. 2016;89:729 e1-6.   PMID: 26851739                                                         doi: http://dx.doi.org/10.1016/j.wneu.2016.01.068
  • Abel TJ, Buckley RT, Morton RP, Gabikian P, Silbergeld DL. Recurrent Supplementary Motor Area Syndrome Following Repeat Brain Tumor Resection Involving Supplementary Motor Cortex. Neurosurgery. 2015;11 Suppl 3:447-56.  PMC4540609
  • Ramakrishna R, Hebb A, Barber J, Rostomily R, Silbergeld D. Outcomes in Reoperated Low-Grade Gliomas. Neurosurgery. 2015;77(2):175-84; discussion 84.
  • Chowdhary MM, Ene CI, Silbergeld DL.  Treatment of Gliomas: How did we get here? Surg Neurol Int 2015;6, Suppl S1:85-8
  • Bobola MS, Alnoor M, Chen JY-S, Kolstoe DD, Silbergeld DL, Rostomily RC, Blank A, Chamberlain MC, Silber JR: O6-methylguanine-DNA methyltransferase activity is associated with response to alkylating agent therapy and with MGMT promoter methylation in glioblastoma and anaplastic glioma. BBA Clinical 2015; 3: 1-10. PMC4280839
  • Kumar A, Boyle EA, Tokita M, Mikheev AM, Sanger MC, Girard E, Silber JR, Gonzalez-Cuyar LF, Hiatt JB, Adey A, Lee C, Kitzman JO, Born DE, Silbergeld DL, Olson JM, Rostomily RC, Shendure J. Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes. Genome biology. 2014;15(12):530. PMID:25608559  PMC: 4272528.
  • Morton RP, Nerva JD, Abecassis IJ, Silbergeld DL, Kim LJ.  Operative cytoreduction for recurrent glioblastoma. World Neurosurgery 2014;82(6):929-31.
  • Ene CI, Silbergeld DL. Predicting prognosis of brain metastasis using molecular and clinical variables. World Neurosurgery 2015; 83(4):490-1. 
  • Adair JE, Johnston SK, Mrugala MM, Beard BC, Guyman LA, Baldock AL, Bridge CA, Hawkins-Daarud A, Gori JL, Born DE, Gonzalez-Cuyar LF, Silbergeld DL, Rockne RC, Storer BE, Rockhill JK, Swanson KR, Kiem HP. Gene therapy enhances chemotherapy tolerance and efficacy in glioblastoma patients. The Journal of clinical investigation. 2014;124(9):4082-92. PMID:25105369  PMC: 4151207
  • Baldock AL, Ahn S, Rockne R, Johnston S, Neal M, Corwin D, Clark-Swanson K, Sterin G, Trister AD, Malone H, Ebiana V, Sonabend AM, Mrugala M, Rockhill JK, Silbergeld DL, Lai A, Cloughesy T, McKhann GM, 2nd, Bruce JN, Rostomily RC, Canoll P, Swanson KR. Patient-specific metrics of invasiveness reveal significant prognostic benefit of resection in a predictable subset of gliomas. PloS One. 2014;9(10):e99057. PMC: 4211670
  • Celix JM, Silbergeld DL:. Cerebral Metastatic Disease: Applying What We Know to Rare Brain Metastases. World Neurosurg 2014; 81(1):50-051.
  • Levitt MR, Levitt R, Silbergeld DL:   Controversies in the Management of Brain Metastases.  Surg Neurol Int 2013;4. (Suppl 4):S231-5. doi: 10.4103/2152-7806.111300. PMCID: PMC3656559.
  • Silbergeld, DL:  Introduction – Supplement on Brain Metastases.  Surg Neurol Int 4:S183-184, 2013. http://www.surgicalneurologyint.com/text.asp?2013/4/5/183/111294  
  • Drane Dl, Roraback-Carson J, Hebb AO, Hersonskey T, Lucas T, Ojemann GA, Lettich E, Silbergeld DL, Miller JW, Ojemann JG:  Cortical Stimulation Mapping and Wada Results Demonstrate a Normal Variant of Right Hemisphere Language Organization.  Epilepsia 2012;53(10):1790-1798.
  • Ko AL, Fink KR, Stelzer KM, Silbergeld DL:  Safety and Efficacy of Concomitant Chemotherapeutic Wafers and Iodine-125 Seeds for Recurrent Glioblastoma.  Surg Neuro Int 2012; 3:137.  PMC3515939
  • Drane DD, Ojemann JG, Phatak V, Loring DW, Gross RE, Hebb AO, Silbergeld DL, Miller JW, Voets NL, Saindane AM, Barsalou L, Meador K, Ojemann GA, Tranel D. Famous face identification in temporal lobe epilepsy: Support for a multimodal integration model of semantic memory. Cortex 2013;49(6):1648-67.
  • Miller KJ, Xu L, Trister A, Rockhill J, Silbergeld DL: Self-reported acalculia as a presenting symptom of non-dominant right parietal glioblastoma, Cureus 2012. 4(5): e44.
  • Adair JE, Beard BC, Trobridge GD, Neff T, Rockhill JK,  Silbergeld DL, Mrugala MM, Kiem H-P:  Extended Survival of Glioblastoma Patients After Chemoprotective HSC Gene Therapy.  Science Translational Medicine  2012;4(133):133ra57. PMC3650895
  • Chowdhary A, Spence AM, Sales L, Rostomily RC, Rockhill JK, Silbergeld DL:  Radiation associated tumors following therapeutic cranial radiation. Surg Neurol Int 2012; 3:48. PMC3356990.
  • Chamberlain MC, Silbergeld DL:  Letter to the Editor:  Is Graded Prognostic Assessment an Improvement Compared with Radiation Therapy Oncology Group’s Recursive Partitioning Analysis Classification for Brain Metastases?  Journal of Clinical Oncology 2012;30(26):3315-6; author reply 6-7.
  • Chamberlain MC, Silbergeld DL:  Surgery, a prognostic marker for progression-free survival?  Neuro-Oncology 2012; 14(4):390-91.
  • Hebb AO, Yang T, Silbergeld DL:  The Sub-Pial Resection Technique for Intrinsic Tumor Surgery.   Surg Neurol International 2011;2:180.
  • Chamberlain MC, Silbergeld DL. Craniopharyngioma. Best Practice .July 2011. http://bestpractice.bmj.com/best-practice/monograph/732.html
  • Chamberlain M C, Silbergeld DL. Craniopharyngioma. BMJ Point-of-Care 2008; www.pointofcare.bmj.com. (July 2011)
  • Silbergeld DL, Hebb AO, Loeser JD:  Vaginal allodynia as the presentation of a thalamic tumor.  Pain 2011; 152:698-702.
  • Levitt MR, Gabikian P, Pottinger PS, Silbergeld DL. Propionibacterium acnes osteomyelitis occurring 23 years after craniotomy: Case report and review of the literature. Neurosurgery 2011; 69(3):E773-E779.
  • Chamberlain MC, Silbergeld DL:  Craniopharyngioma. (Monograph).  BMJ Point of Care, 2010.
  • Abel TJ, Hebb AO, Keene CD, Born DE, Silbergeld DL: Parahippocampal Corpora Amylacea.  Case Report.  Neurosurgery 2010; 66(6):E1206-7.
  • Abel TJ, Hebb AO, Silbergeld DL:  Cortical stimulation mapping in a patient with foreign accent syndrome.  Clinical Neurology and Neurosurgery 2009: 111:97-101.
  • Drane DL, Ojemann GA, Ojemann JG, Aylward E, Silbergeld DL, Miller JW, Tranel D.  Category-specific recognition and naming deficits following resection of a right anterior temporal lobe tumor in a patient with atypical language lateralization. Cortex 2009; 45(5):630-640.
  • Drane DL, Ojemann GA, Aylward E, Ojemann JG, Johnson LC, Silbergeld DL, Miller JW, Tranel D:  Category-specific Naming and Recognition Deficits in Temporal Lobe Epilepsy Surgical Patients.  Neuropsychologia 2008; 46(5):1242-1255.
  • Spence AM, Muzi M, Swanson KR, O’Sullivan F, Rockhill JK, Rajendran JG, Adamsen TCh, Link JM, Swanson PE, Yagle KJ, Rostomily RC, Silbergeld DL, Krohn KA: Regional hypoxia in glioblastoma multiforme quantified with [F-18]- Fluoromisonidazole (FMISO) PET before radiotherapy: Correlation with time to progression and survival. Clinical Cancer Res 2008, 14(9):2623-2630.
  • Stelzer KJ, Douglas JG, Mankoff DA, Silbergeld DL, Krohn KA, Laramore GE, Spencce AM.  Positron emission tomography-guided conformal fast neutron therapy for glioblastoma multiforme.  Neuro Oncol 2008, 10(1):88-92.
  • Stelzer KJ, Mesiwala AH, Farrokhi FR, Silbergeld DL:  Posterior Cerebral Artery Compression and Subsequent Infarction after Implantation of a GliaSite™ Balloon.  The Internet Journal of Oncology 2007; Volume 4, No. 1.
  • Rostomily RC, Elias MC, Deng M, Elias, P, Born DE, Muballe KD, Silbergeld DL, Futran N, Weymuller EA, Mankoff DA, Eary J:  Clinical utility of somatostatin receptor scintigraphic imaging (Octreoscan) in esthesioneuroblastoma;  A case study and survey of somatostatin receptor sub-type expression.  Head and Neck 2006; (28)4: 305-312.
  • Elias MC, Tozer KR, Silber JR, Mikheeva S, Deng M, Morrison RS, Manning TC, Silbergeld DL, Glackin CA, Reh TA, Rostomily RC:  TWIST is expressed in human gliomas and promotes invasion.  Neoplasia 2005; 7(9):824-837.
  • Douglas JG, Stelzer KJ, Mankoff DA, Tralins KS, Krohn KA, Muzi M, Silbergeld DL, Rostomily RC, Scharnhorst J, Spence AM:  [F-18]-fluorodeoxyglugcose positron emission topography for targeting radiation dose escalation for patients with glioblastoma multiforme:  clinical outcomes and patterns of failure.  Int J Radiat Oncol Biol Phys  2006. 64:886-891.
  • Mourad PD and Silbergeld DL:  Breaking the Blood-Brain Barrier.  RT Image 2005; 18:29-32.
  • Englund C, Alvord EC Jr., Folkerth RD, Silbergeld D, Born DE, Small R, Hevner RF:  NeuN expression correlates with reduced mitotic index of neoplastic cells in central neurocytomas.  Neuropath and Appl Neurobiol, 2005;31(4):429-438.
  • Bobola M, Emond M, Blank A, Meade EH, Kolstoe D, Berger MS, Rostomily RC, Silbergeld DL, Spence AM, Silber J:  Apurinic endonuclease activity in adult gliomas and time to tumor progression after alkylating agent-based chemotherapy and after radiotherapy.  Clin Cancer Res 2004;10:7875-7883.
  • Mourad PD, Farrell L, Stamps LD, Chicoine MR, Silbergeld DL:  Why are Systemic Glioblastoma Metastases Rare?  Systemic and Cerebral Growth of Mouse Glioblastoma.  Surg Neurol 2005;63:511-519.
  • Spence AM, Peterson RA, Scharnhorst JD, Silbergeld DL, Rostomily RC. Phase II study of concurrent continuous Temozolomide (TMZ) and Tamoxifen (TMX) for recurrent malignant astrocytic gliomas. Journal of Neuro-Oncology. 2004;70(1):91-5.
  • Holmes MD, Silbergeld DL, Drouhard D, Wilensky AJ, Ojemann LM: Effect of vagus nerve stimulation in adults with pharmacoresistant generalized epilepsy syndromes. Seizure 2004;13:340-345.
  • Douglas JG, Silbergeld DL, Laramore GE:  Gamma knife stereotactic radiosurgical boost for patients treated primarily with neutron radiotherapy for salivary gland neoplasms.  Stereotact Func Neurosurg 2004;82:84-89.
  • Englund C, Silbergeld D, Alvord EC, Small R, Hevner, RF.  A 24 year-old woman with bifrontal headaches. Brain Pathol, 2004;14:341-342.
  • Mesiwala AH, Farrell L, Santiago P, Ghatan S, Silbergeld DL:  The effects of hydrogen peroxide on brain and brain tumors.  Surg Neurol 2003; 59:398-407.
  • Mourad PD, Farrell L, Stamps LD, Santiago P, Filmore HL, Broaddus WC, Silbergeld DL.  Quantitative Assessment of Glioblastoma Invasion in vivo. Cancer Letters 2003; 192(1):97-107.
  • Silbergeld DL, Rostomily RC. Resection of glioblastoma. Journal of Neurosurgery. 2002;96(4):809; author reply 10. PMID:11990830
  • Grant, GA, Farrell D, Silbergeld DL:  Continuous somatosensory evoked potential monitoring during brain tumor resection.  J Neurosurg, 2002 97(3):709-713.
  • Tralins, KS, Douglas JG, Stelzer KJ, Mankoff, DA, Silbergeld, DL, Rostomily R, Hummel, S, Scharnhorst J, Krohn KA, Spence AM:  Volumetric Analysis of 18F-FDG PET in Glioblastoma Multiforme:  Prognostic Information and Possible Role in Definition of Target Volumes in Radiation Dose Escalation. J Nucl Med, 2002; 43:1667-1673.
  • Mesiwala AH, Farrell L, Wenzel HJ, Silbergeld DL, Crum LA, Winn HR, Mourad PD:  High Intensity Focused Ultrasound Selectively Disrupts the Blood-Brain Barrier in vivo.  Ultrasound Med & Biol 2002; 28:389-400.
  • Duntley SP, Kim A, Silbergeld DL, Miller JW:  Characterization of the Mu Rhythm during REM Sleep. Clin Neurophysiol, 2001; 112(3):528-31.
  • Freeman WJ, Rogers LJ, Holmes MD, Silbergeld DL: Spatial Spectral Analysis of Human Electrocorticograms Including the Alpha and Gamma Bands, J Neurosci. Methods 2000; 95(2):111-121.
  • Silbergeld DL: Controversies in Neurosurgery - Primary Brain Tumors: Resective Surgery Versus Biopsy and Adjuvant Therapy:  The Case for Biopsy and Adjuvant Therapy.  Clinical Neurosurg 1999; 45:218-220.
  • Sherburn EW, Bahn MM, Gokden M, Silbergeld DL, Rich KM:  Dysembryoplastic neuroepithelial tumor and oligodendroglioma: The diagnostic value of magnetic resonance spectroscopy. Neurosurg Focus 1998; 4:1-8.
  • Werth JL, Park TS, Silbergeld DL, Rothman SM:  Excitotoxic swelling occurs in oxygen and glucose deprived human cortical slices. Brain Research 1998; 782:248-254.
  • Ojemann JG, Neil JM, MacLeod A-M, Silbergeld DL, Dacey RG, Petersen SE, Raichle Me:  Increased Functional Vascular Response in the Region of a Glioma. J Cerebral Blood Flow and Metab 1998; 18(2):148-153.
  • Silbergeld DL:  Extent of Medial Temporal Resection on Outcome from Anterior Temporal Lobectomy: A Randomized Prospective Study. Neurosurgery 1997; 41(1):327-8.
  • Silbergeld DL, Chicoine MR:  Tumor in Normal Brain: Response. J Neurosurg 1997; 87(3):485.
  • Bahn MM, Lin W, Silbergeld DL, Miller JW, Kuppusamy K, Cook R, Wetzel R, Hammer G, Cross D: Localization of language cortices by functional MR imaging compared with intracarotid amobarbital hemispheric sedation.  Am J Roentgenol 1997; 169:575-579.
  • Silbergeld DL, Sherburn EW: Acrylic cranioplasty using miniplate struts. Neurosurgery. 1997; 40(4):885-6.
  • Silbergeld DL, Chicoine MR:  Isolation and characterization of human malignant glioma cells from histologically normal brain.  J Neurosurg. 1997; 86(3):525-31.
  • Chicoine MR, Silbergeld DL:  Mitogens as motogens.  J Neuro-Oncol. 1997 35:249-257.
  • Park TS, Silbergeld DL, Bourgeois BFD, Dodson WE:  Subtemporal transpara-hippocampal amygdalohippocampectomy for mesial temporal lobe epilepsy. Technical note. J Neurosurg. 1996 85:1172-1176.
  • Silbergeld DL, Moran CJ:  Early postoperative imaging: Response.  J Neurosurg 1996; 85:523.
  • Silbergeld DL:  Tumors of Heschl’s Gyrus: Report of two cases.  Neurosurgery 1997; 40:389-392.
  • Henegar MM, Silbergeld DL:  Pharmacology for Neurosurgeons, Part II: Anesthetic agents, ICP management, steroids and cerebral protectants.  Contemp Neurosurg 1996; 18(13):1-7.
  • Chicoine MR, Silbergeld DL:  Pharmacology for Neurosurgeons, Part I: Anti-convulsants, antibiotics, chemotherapeutics.  Contemp Neurosurg 1996; 18(12):1-6.
  • Silbergeld DL, Miller JW:  Intraoperative cerebral mapping and monitoring.  Contemp Neurosurg 1996; 18(11),1-6.
  • Sherburn EW, Silbergeld DL:  A new method of acrylic cranioplasty.  Surg Neurol 1996; 46:292-294
  • Gutmann DH, Giordano MJ, Mahadeo DK, Lau N, Silbergeld DL, Guha A:  Increased neurofibromatosis 1 gene expression in astrocytic tumors: positive regulation by p21-ras.  Oncogene 1996; 12(10):2121-2127.
  • Ojemann JG, Miller JW, Silbergeld DL:  Preserved function in brain invaded by tumor.  Neurosurgery 1996 39(2):253-258; discussion 258-9.
  • Cheng MA, Tempelhoff, Thread MA, Silbergeld DL, Miller JW, Haines S:  Large dose propofol alone in adult epileptic patients:  Electrocorticographic results.  Anesth Analg 1996; 83:169-174
  • Henegar MM, Koby MB, Silbergeld DL, Moran CJ, Rich KM:  Intrasellar Abscess Following Transsphenoidal Surgery: Two Case Reports and Literature Review.  Surg Neurol 1996; 45:183-188.
  • Henegar MM, Vollmer DG, Silbergeld DL:  Intraoperative transligamentous ultrasound in the evaluation of thoracic intraspinal pathology: Technique.  Spine 1996; 21:124-127.
  • Henegar MM, Moran CJ, Silbergeld DL:  Early postoperative magnetic resonance imaging following non-neoplastic cortical resection.  J Neurosurg 1996; 84:174-179.
  • Silbergeld DL, Ojemann JG, Chicoine MR: Cortical mapping demonstrates human somatosensory gyrus is larger than motor gyrus.  J Epilepsy 1995; 8(3):246-249.
  • Chicoine MR, Silbergeld DL:  In Vitro Motility of Human Gliomas Increases with Increasing Grade of Malignancy.  Cancer 1995;75(12):2904-2909.
  • Silbergeld DL, Chicoine MR, Madsen CL:  In vitro assessment of taxol for human glioblastoma:  Chemosensitivity and cellular locomotion.  Anti-Cancer Drugs 1995, 6(2):270-276.
  • Chicoine MR, Silbergeld DL:  Invading C6 Glioma Cells Maintaining Tumorgenicity.  J Neurosurgery 1995;83:665-671.
  • Chicoine MR, Madsen CL, Silbergeld DL:  Modification of human glioma locomotion in vitro by cytokines EGF, bFGF, PDGFbb, NGF, and TNF alpha.  Neurosurgery 1995;36(6):1165-70; discussion 1170-71.
  • Silbergeld DL, Vollmer DG, Tantuwaya VS, Eichler ME:  Endoscopic Transventricular Hippocampectomy.  J Epilepsy  1995;8:68-73
  • Ojemann JG, Silbergeld DL:  Cortical Stimulation Mapping of Phantom Limb Rolandic Cortex.  J Neurosurg  1995;82(4):641-644.
  • Giordano MJ, Commins D, Silbergeld DL:  Sjogren's Cerebritis Complicated by Subarachnoid Hemorrhage and Bilateral Superior Cerebellar Artery Occlusion: Case Report.  Surg Neurol 1995;43(1):48-51.
  • Chicoine MR, Silbergeld DL:  Assessment of Brain Tumor Cell Motility in vitro and in vivo.  J Neurosurg 1995;82(4):615-622.
  • Gannett DE, Wisbeck WM, Silbergeld DL, Berger MS:  The Role of Postoperative Irradiation in the Treatment of Oligodendroglioma.  Int J Rad Oncol Biol Phys 1994;30(3):567-573.
  • Silbergeld DL, Miller JD:  Resective Surgery for Medically Intractable Epilepsy Associated with Schizencephaly  J Neurosurg 1994;80(5):820-825.
  • Silbergeld DL:  Intraoperative Transdural Functional Mapping:  Technical Note.  J Neurosurg 1994;80(4):756-758.
  • Weber JP, Silbergeld DL, Winn HR: Surgical Resection of Epileptogenic Cortex Associated with Structural Lesions.  Neurosurg Clinics North Amer 1993; 4(2):327-336.
  • Silbergeld DL, Ojemann GA: The Tailored Temporal Lobectomy.  Neurosurg Clinics North Amer 1993; 4(2):273-282.
  • Ojemann GA, Silbergeld DL: Approaches to Epilepsy Surgery.  Neurosurg Clinics North Amer 1993; 4(2):183-192.
  • Silbergeld DL:  A New Device For Cortical Stimulation Mapping Of Surgically Unexposed Cortex:  Technical Note.  J Neurosurg 1993;79(4):612-614.
  • Silbergeld DL, Mayberg MR, Berger MS, Ali-Osman F, Kelly WA, Shaw CM:  Pituitary Oncocytomas:  Clinical Features, Characteristics in Cell Culture and Treatment Recommendations.  J Neuro-Oncol 1993;16:39-46.
  • Pilcher WH, Silbergeld DL, Berger MS, Ojemann GA:  Intraoperative Electro-corticography During Tumor Resection:  Impact on Seizure Outcome in Patients with Gangliogliomas.  J Neurosurg 1993;78:891-902.
  • Silbergeld DL, Mueller WM, Colley PS, Ojemann GA, Lettich E. Use of propofol (Diprivan) for awake craniotomies: technical note. Surgical Neurology. 1992;38(4):271-2. PMID:1440214.
  • Berger MS, Sundsten J, Lemire RJ, Silbergeld D, Newell D, Shurtleff D. Pathophysiology of isolated lateral ventriculomegaly in shunted myelodysplastic children. Pediatric neurosurgery. 1990;16(6):301-4.
  • Silbergeld DL, Griffin BG, Ojemann GA: Reirradiation for Recurrent Supratentorial Astrocytomas: Case Report and Review of the Literature J Neuro-Oncol 1992;12:145-151.
  • Silbergeld DL, Ali-Osman F, Winn HR: Induction of Transformational Changes in Normal Endothelial Cells by Glioblastoma Cells in Culture.  J Neurosurg 1991;75:604-612.
  • Silbergeld DL, Ali-Osman F: Isolation and Characterization of Microvessels from Normal Brain and Brain Tumors. J Neuro-Oncol 1991;11:49-55.
  • Silbergeld DL, Rostomily RC, Alvord EC: The Cause of Death in Patients with Glioblastoma is Multifactorial: Clinical Factors and Autopsy Findings in 117 Cases of Supratentorial Glioblastoma in Adults. J Neuro-Oncol 1991;10:179-185.
  • Silbergeld DL, Harkness WF, Bell BA, Bircher MD. Posterior fracture dislocation of the shoulder secondary to epileptic seizures. Journal of the Royal College of Surgeons of Edinburgh. 1991;36(2):139-40. PMID:2051416.
  • Silbergeld DL, Laohaprasit V, Grady MS, Anderson PA, Winn HR. Two cases of fatal atlantoaxial distraction injury without fracture or rotation. Surgical neurology. 1991;35(1):54-6.
  • Silbergeld DL, Harkness WJ, Wilkins P, Bell BA: Subdural Bone in a Patient with Glioblastoma Multiforme. Brit Med J 1990;4:349-552.
  • Silbergeld DL, Ojemann GA, Laohaprasit V, Eskridge J, Winn HR: Postoperative CT Enhancement Following Lobectomy for Epilepsy: Response. J Neurosurg. 1991;74:689.
  • Laohaprasit V, Silbergeld DL, Ojemann GA, Eskridge J, Winn HR: Postoperative CT Enhancement Following Lobectomy for Epilepsy. J Neurosurg 1990;73:392-395.
  • Silbergeld DL: Views on Microvascular Decompression. J Neurosurgery 1989;71:463.
  • Silbergeld DL, Berger MS, Griffin G: Sylvian Fissure Meningioma in Childhood: Case Report and Review of the Literature. Ped Neurosci 1988;14:50-53.
  • Silbergeld DL, Berger MS, Griffin B, Bleyer A, Geyer R, Milstein J, Eskridge J: Brainstem Glioma with Multiple Metastases During Life: Case Report and Review of Literature. Ped Neurosci 1988;14:103-107.
  • Dhib-Jalbut S, Hesslebrock R, Brott T, Silbergeld D: Treatment of Neuroleptic Malignant Syndrome with Bromocriptine. (letter) JAMA 1983; 250:484-485.




  1. Celix J, Silbergeld D. Intraoperative Cortical Mapping Techniques and Limitations. In Byrne RW(ed): Functional Mapping of the Cerebral Cortex: Safe Surgery in Eloquent Brain. New York, Springer International Publishing, 2016, pp 63-76.
  2. Silbergeld DL:  Editor, Brain Metastases- Supplement:  Surgical Neurology International Online Journal, 2013, Vol 4, Issue Supp http://www.surgicalneurologyint.com/text.asp?2013/4/5/183/111294
  3. Celix J, Silbergeld D. Metastatic Brain Tumors. In: Ellenbogen R, Abdulrauf S, editors. Principles of Neurological Surgery. 3rd ed. Philadelphia: Saunders; 2012. Chapter 35, p. 535-46.
  4. Silbergeld DL, Hebb AO: Awake Craniotomy in Jandial R, McCormick PD, Black PM (eds): Core Techniques in Operative Neurosurgery (pp. 279-283) Chapter 39, Philadelphia, Elsevier, 2011, p. 279-28
  5. Silbergeld DL:  Neurosurgical Management of Gliomas in Navarro VG (ed): Neurosurgery Textbook for Residents (Spanish edition), publication pending.
  6. Silbergeld DL: Awake Craniotomies and Functional Mapping, in, Connolly ES, McKhann GM, Huang J, Choudhri TF, Komotar RJ, Mocco J (eds): Fundamentals of Operative Techniques in Neurosurgery.  New York, Thieme Medical Publishers, 2010 (second edition). Chapter 60.
  7. Silbergeld DL, Ward AA: Temporal Gliomas in, Connolly ES, McKhann GM, Huang J, Choudhri TF, Komotar RJ, Mocco J (eds): Fundamentals of Operative Techniques in Neurosurgery.  New York, Thieme Medical Publishers, 2010 (second edition). Chapter 44.
  8. Spence AM, Mankoff DA, Wells, JM, Muzi M, Grierson JR, Eary J, O’Sullivan SF, Link JM, Silbergeld DL, Krohn KA:  Detection of Proliferation in Gliomas by Positron Emission Topography Imaging in Janigro D (ed), Cell Cycle in the Central Nervous System.  Totowa NJ, Humana Press, Inc.  2006, 419-432.
  9. Silbergeld DL: Temporal Glioma, in Connolly ES, McKhann GM, Huang J, Choudhri TF, Mocco J (eds): Fundamentals of Operative Techniques in Neurosurgery.  New York, Thieme Medical Publishers, 2006 (first edition).
  10. Silbergeld DL:  Awake Craniotomies and Functional Mapping, in Connolly ES, McKhann GM, Huang J, Choudhri TF, Mocco J (eds): Fundamentals of Operative Techniques in Neurosurgery.  New York, Thieme, 2006 (first edition)
  11. Silbergeld DL, Miller JW (eds):  Epilepsy Surgery: Principles and Controversies.  New York, CRC Press, Taylor and Francis, 2006.

       11a: Review of language mapping procedures for temporal resections (Lucas T and Silbergeld DL);

       11b:  Neocortical resections and lesionectomies (Tozer K and Silbergeld DL)

       11c:  Lesionectomies should be tailored based on ictal recording (Rostomily RC and Silbergeld DL); pp 537-541.

       11d: Functional hemispherectomy (Silbergeld DL)

  1. Dahl E, Nguyen LT, Sparks RE, Brayman AA, Ollos, RJ, Silbergeld DL, Vaezy S, Mourad PD: Towards the Use of HIFU, in Conjunction with Surgery, for the Treatment of Malignant Brain Tumors, in Therapeutic Ultrasound, Proceedings of the Fifth International Symposium, G.T. Clement, N.J. McDannold and K. Kynynen, eds., 218-222, American Institute of Physics Press, 2006.
  2. Rostomily RC, Spence AM, Silbergeld DL: Neurosurgical Management of high grade gliomas, in Moore AJ, Newell DW (eds): International Practices in Neurosurgery. London, Springer Verlag, 2004, Chap 10, pp 167-186.
  3. Silbergeld DL: Section Editor, Epilepsy Surgery, in Youman’s Neurological Surgery, Fourth Edition, WB Saunders Co., Philadelphia, 2003; Volume 2.
  4. Santiago P, Silbergeld DL:  Malignant Gliomas in Youman’s Neurological Surgery, ed Winn HR, Fourth Edition, WB Saunders Co., Philadelphia, 2003. pp 969-981.
  5. Schuster J, Silbergeld DL: Motor, Sensory and Language Mapping and Monitoring for Cortical Resections in Youman’s Neurological Surgery, ed. Winn HR,  Fourth Edition, WB Saunders Co., Philadelphia, 2003. pp. 2531-2541.
  6. Silbergeld DL- Expert Commentator. in: Fundamentals of Operative Techniques in Neurosurgery, Eds: Connolly ES, McKhann GM, Huang J and Choudri TF, Thieme Medical Publishers, Inc., New York, 2002. Temporal Approach, p227; Glioma – Temporal, p451; Stereotactic Biopsy for Basal Ganglia and Deep Lesions, p463; Metastatic Tumor, p503; Temporal Lobectomy and Hippocampectomy, p512; Subdural Grid Placement, pp518-519; StereotacticPlacement of Depth Electrodes, p524; Neocortical Mapping and Awake Operations, pp531-532.
  7. Silbergeld DL: Cortical Mapping in Epilepsy Surgery. Eds: Luders HO and Comair YG, Lippincott Williams and Wilkins, Philadelphia, pp 633-635; 2002.
  8. Santiago P, Silbergeld DL: Pharmacology and Utility of Common Neurosurgical Drugs, in Textbook of Neurological Surgery, 2nd Edition, Lippincott Williams and Wilkins, 2001.
  9. Silbergeld DL (Senior Editor) and Ojemann GA: Neurosurgery Clinics of North America: Epilepsy Surgery. WB Saunders Co., Philadelphia Vol 4, No 2, 1993



  1. Silbergeld DL:  Editor, Textbook- Glioma Controversies: Basic Science, Diagnosis, and Treatment, Elsevier / Academic Press, pending, 2015.

  2. Silbergeld DL, Miller JW (eds):  Epilepsy Surgery: Principles and Controversies.  New York, Marcel Dekker, 2005.     

  3. Silbergeld DL (Senior Editor) and Ojemann GA: Neurosurgery Clinics of North America: Epilepsy Surgery. WB Saunders Co., Philadelphia Vol 4, No 2, 1993


OTHER PUBLICATIONS (non-refereed journals and letters to the editor) (numbered)


  1. Greenfield JP, Gutin PH, Liau LM, Silbergeld DL, Kaye AH, Glick RP: Angiogenesis and Gliomas: Current Issues and Development of Surrogate Markers - Comments. Neurosurgery 62(1): 50-52, 2008. 
  2. Friedman AH, Brennan C, Gutin PH, Barnett GH, Silbergeld DL, Piepmeier JM: Extent of Resection and Survival on Glioblastoma Multiforme-Identification of and Adiustment for Bias - Comments. Neurosurgery 62(3): 574-576, 2008.
  3. Silbergeld DL, Kaye AH, Barker FG, Kitchen N: Impact of Brain Biopsy on the Management of Patients with Nonneoplastic Undiagnosed Neurological Disorders - Comments. Neurosurgery 62(4): 837-838, 2008.
  4. Kim PE, Berger MS, Silbergeld DL: Fluorescent in Situ Hybridization and Ex Vivo H-1 Magnetic Resonance Spectroscopic Examinations of Meningioma Tumor Tissue: Is It Possible to Identify a Clinically-Aggressive Subset of Benign Meningiomas? Comments. Neurosurgery 61(5): 1060-1061, 2007.
  5. Cobbs C, Gutin PH, Oyesiku NM, Silbergeld DL, Glick RP, Scott RM: Increased Prevalence of Obesity and Obesity Related Postoperative Complications in Male Patients with Meningiomas - Comments. Neurosurgery 61(4): 760-761, 2007.
  6. Liau LM, Rock JP, Silbergeld DL: Clinical Significance of Abca2, a Possible Molecular Marker for Oligodendrogliomas - Comments. Neurosurgery 60(4): 714-714, 2007. 
  7. Broggi G, Silbergeld DL, Nimsky C, Berger MS, Schramm J: Intraoperative Subcortical Language Tract Mapping Guides Surgical Removal of Gliomas Involving Speech Areas - Comments. Neurosurgery 60(1): 80-82, 200
  8. Brem H, Boulton M, Rutka JT, Glick R, Silbergeld DL: Treatment of Malignant Gliomas with Mitoxantrone-Loaded Poly (Lactide-Co-Glycolide) Microspheres - Comments. Neurosurgery 59(6): 1302-1303, 2006.
  9. Silbergeld DL, Mikkelsen T, Rosenblum ML: Glioblastoma and Cerebral Microvascular Endothelial Cell Migration in Response to Tumor-Associated Growth Factors - Comments. Neurosurgery 52(6): 1399-1399, 2003.



  1. The Videographer Awards, 2006, “Inside Access:  Brain Tumor Surgery,” University of Washington Medical Center, Seattle, WA.

  2. 2006 Telly Award, “Inside Access:  Brain Tumor Surgery,” University of Washington Medical Center, Seattle, WA.

  3. The 2005 Aurora Awards – Gold Award, “Inside Access:  Brain Tumor Surgery”, University of Washington Medical Center, Seattle, WA.