Mahesh Karandikar, MD, PhD

Mahesh Karandikar
Job Title
Clinical Assistant Professor of Neurological Surgery

After my fellowship training, I spent 9 years in private practice.  The practice was approximately 75% spine and 25% cranial neurosurgery.

Clinical Interest

I am interested in engaging patients in tracking their own short term and long term outcomes to the various degenerative spinal procedures, both surgical and non-surgical. We have great interest in collaborating with medical companies to participate in clinical trials.  The focus of these trials is on introducing innovative techniques that may lead to better patient outcomes.


Medical Education
UT Southwestern Medical Center

University of Washington

University of Pittsburgh – Pediatric Neurosurgery
Johns Hopkins University – Spine

Board Certification
American Board of Neurological Surgery - 2017
  1. Karandikar M, Mirza SK, Song K, Yang T, Krengel WF 3rd, Spratt KF, Avellino AM.  Complex pediatric cervical spine surgery using smaller nonspinal screws and plates and intraoperative computed tomography.  J Neurosurg Pediatr. 2012 Jun;9(6):594-601. doi: 10.3171/2012.2.PEDS11329. PMID: 22656248
  2. Shurtleff H, Warner M, Poliakov A, Bournival B, Shaw DW, Ishak G, Yang T, Karandikar M, Saneto RP, Browd SR, Ojemann JG. Functional magnetic resonance imaging for presurgical evaluation of very young pediatric patients with epilepsy. J Neurosurg Pediatr. 2010 May;5(5):500-6. doi: 10.3171/2009.11.PEDS09248. PMID: 20433264
  3. Browd SR, Zauberman J, Karandikar M, Ojemann JG, Avellino AM, Ellenbogen RG. A new fiber-mediated carbon dioxide laser facilitates pediatric spinal cord detethering. Technical note. J Neurosurg Pediatr. 2009 Sep;4(3):280-4. doi: 10.3171/2009.4.PEDS08349. PMID: 19772415
  4. Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, Berman K, Cobb MH. Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.  Endocr Rev. 2001 Apr;22(2):153-83. doi: 10.1210/edrv.22.2.0428. PMID: 11294822
  5. Karandikar M, Xu S, Cobb MH. MEKK1 binds raf-1 and the ERK2 cascade components.J Biol Chem. 2000 Dec 22;275(51):40120-7. doi: 10.1074/jbc.M005926200. PMID: 10969079
  6. Karandikar M, Cobb MH. Scaffolding and protein interactions in MAP kinase modules. Cell Calcium. 1999 Nov;26(5):219-26. doi: 10.1054/ceca.1999.0074. PMID: 10643560
  7. English J, Pearson G, Wilsbacher J, Swantek J, Karandikar M, Xu S, Cobb MH. New insights into the control of MAP kinase pathways. Exp Cell Res. 1999 Nov 25;253(1):255-70. doi: 10.1006/excr.1999.4687. PMID: 10579927
  8. Krenger W, Cooke KR, Crawford JM, Sonis ST, Simmons R, Pan L, Delmonte J Jr, Karandikar M, Ferrara JL. Transplantation of polarized type 2 donor T cells reduces mortality caused by experimental graft-versus-host disease. Transplantation. 1996 Nov 15;62(9):1278-85. doi: 10.1097/00007890-199611150-00018. PMID: 8932272
  9. Pan L, Bressler S, Cooke KR, Krenger W, Karandikar M, Ferrara JL. Long-term engraftment, graft-vs.-host disease, and immunologic reconstitution after experimental transplantation of allogeneic peripheral blood cells from G-CSF-treated donors. Biol Blood Marrow Transplant. 1996 Oct;2(3):126-33. PMID: 9199755
  10. Falzarano G, Krenger W, Snyder KM, Delmonte J Jr, Karandikar M, Ferrara JL. Suppression of B-cell proliferation to lipopolysaccharide is mediated through induction of the nitric oxide pathway by tumor necrosis factor-alpha in mice with acute graft-versus-host disease. Blood. 1996 Apr 1;87(7):2853-60. PMID: 8639904