Jacob J. Ruzevick, MD

Headshot - Jacob J. Ruzevick, MD
Job Title
Assistant Professor of Neurological Surgery

Dr. Jacob Ruzevick is an assistant professor of Neurological Surgery and fellowship trained neuro-oncology and skull base surgeon at the University of Washington School of Medicine. He received his undergraduate degree from the Massachusetts Institute of Technology and his medical doctorate from the Johns Hopkins University School of Medicine. He completed his residency in neurological surgery at the University of Washington and fellowship in skull base and minimal invasive cranial surgical oncology at the University of Southern California under the guidance of Dr. Gabriel Zada. He treats the entire spectrum of cranial oncology, including intrinsic and skull base tumors, at the University of Washington Medical Center, Seattle Children’s Hospital, and Harborview Medical Center. 

Clinical Interest

Neuro-oncology, endoscopic cranial surgery, minimally invasive cranial surgery, awake-language mapping, functional brain mapping, fluorescence-guided surgery

Personal Interests

Running, golf, exploring the Pacific Northwest


Medical Education: Johns Hopkins University School of Medicine

Residency: University of Washington School of Medicine, Department of Neurological Surgery


Peer reviewed publications

  1. Jackson C, Ruzevick J, Phallen J, Belcaid Z, Lim M. Challenges in immunotherapy presented by the glioblastoma multiforme microenvironment. Clinical and Developmental Immunology. 2011 Oct; 2011(2011): 1-20. PMID: 22190972.
  2. Pradilla G, Garzon-Muvdi T, Ruzevick J, Bender M, Edwards L, Momin E, Thompson R, Tamargo R. Systemic L-citrulline prevents cerebral vasospasm in haptoglobin 2-2 transgenic mice after subarachnoid hemorrhage. Neurosurgery. 2012 Mar; 70(3): 747-756. PMID: 21915076.
  3. Ruzevick J, Jackson C, Phallen J, Lim M. Clinical trials with immunotherapy for high-grade glioma. Neurosurg Clin N Am. 2012 Jul; 23(3): 459-70. PMID: 22748658.
  4. Jackson C, Ruzevick J, Amin A, Lim M. Potential role for STAT3 inhibitors in glioblastoma. Neurosurg Clin N Am. 2012 Jul; 23(3): 379-89. PMID: 22748651.
  5. See A, Han J, Phallen J, Binder Z, Gallia G, Pan F, Jinasena D, Jackson C, Belcaid Z, Jeong S, Gottschalk C, Zeng J, Ruzevick J, Nicholas S, Kim Y, Albesiano E, Pardoll D, Lim M. The role of STAT3 activation in modulating the immune microenvironment of GBM. J Neurooncol. 2012 Dec; 110(3): 359-368. PMID: 23096132.
  6. Ruzevick J, Jackson C, Pradilla G, Garzon-Muvdi T, Tamargo R. Aneurysm formation in proinflammatory, transgenic haptoglobin 2-2 mice. Neurosurgery. 2013 Jan; 72(1): 70-76. PMID: 23096414.
  7. Jackson C, Ruzevick J, Brem H, Lim M. Vaccine strategies for glioblastoma: progress and future directions. Immunotherapy. 2013 Feb; 5(2): 155-67. PMID: 23413907.
  8. Ruzevick J, Olivi A, Westra WH. Metastatic squamous cell carcinoma to the brain: an unrecognized pattern of distant spread in patients with HPV-related head and neck cancer. J Neurooncol. 2013 May; 112(3): 449-454. PMID: 23408186.
  9. Zeng J, See A, Phallen J, Jackson C, Belcaid Z, Ruzevick J, Durham N, Meyer C, Harris T, Albesiano E, Pradilla G, Ford E, Wong J, Hammers H, Mathios D, Tyler B, Brem H, Tran P, Pardoll D, Drake C, Lim M. Anti-PD-1 blockade and stereotactic radiation produce long term survival in mice with intracranial gliomas. Int J Radiat Oncol Biol Phys. 2013 June 1; 86(2): 343-349. PMID: 23462419.
  10. Nicholas S, Mathios D, Ruzevick J, Jackson C, Yang I, Lim M. Current trends in glioblastoma multiforme treatment: radiation therapy and immune checkpoint inhibitors. BTRT. 2013 April; 1(1): 2-8. PMID: 24904882
  11. Garzon-Muvdi T, Pradilla G, Ruzevick J, Bender M, Edwards L, Grossman R, Zhao M, Rudek M, Riggins G, Levy A, Tamargo R. Inhibition of experimental cerebral vasospasm in a murine subarachnoid hemorrhage model using S-4-Carboxyphenylgicine (S-4-CGP), a metabotropic glutamate receptor antagonist. Neurosurgery. 2013 Oct; 73(4): 710-728. PMID: 23842553.
  12. Siu IM, Ruzevick J, Zhao Q, Connis N, Burger P, Hann C, Gallia G. Erlotinib inhibits growth in a patient-derived chordoma xenograft. PLoS ONE. 2013 Nov; 8(11)e78895. PMID: 24260133.
  13. Ruzevick J, Kleinberg L, and Rigamonti D. Imaging changes following stereotactic radiosurgery for metastatic intracranial tumors: differentiating pseudoprogression from tumor recurrence and its effect on clinical practice. Neurosurgical Review. 2014 Apr; 37(2):193-201. PMID: 24233257.
  14. Ruzevick J, Nicholas S, Redmond K, Kleinberg L, Lipson E, and Lim M. Case Report: A patient with HIV treated with ipilimumab and stereotactic radiosurgery for melanoma metastases to the brain. Case Reports in Oncological Medicine. 2013; 2013:946392. PMID: 24383025.
  15. Kim J, Patel M, Ruzevick J, Jackson C, Lim M. STAT3 activation in glioblastoma: biochemical and therapeutic implications. Cancers. 2014 Feb 10;6(1): 376-395. PMID: 24518612.
  16. Wicks R, Huang Y, Zhang K, Zhao M, Tyler B, Suk I, Hwang L, Ruzevick J, Jallo G, Brem H, Pradilla G, Kang J. Extravascular optical coherence tomography: evaluation of carotid artery atherosclerosis and pravastatin therapy in the apolipoprotein E deficient mouse. Stroke. 2014 Apr; 45(4): 1123-1130. PMID: 24627118.
  17. Walker A, Ruzevick J, Malayeri A, Rigamonti D, Lim M, Redmond K, Kleinberg L. Postradiation imaging changes in the CNS: how can we differentiate between treatment effect and disease progression. Future Oncology. 2014 May; 10(7): 1277-1297. PMID: 24947265.
  18. Belcaid Z, Phallen J, Zeng J, See A, Mathios D, Gottschalk C, Nicholas S, Kellet M, Ruzevick J, Jackson C, Albesiano E, Durham N, Ye X, Tran P, Tyler B, Wong J, Brem H, Pardoll D, Drake C, Lim M. Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model. PLoS One. 2014 Jul; 9(7): e101764. PMID: 25013914.
  19. Patel M, Kim J, Ruzevick J, Li G, Lim M. The future of glioblastoma therapy: synergism of standard of care and immunotherapy. Cancers. 2014 Sep; 6(4): 1953-1985. PMID: 25268164.
  20. Mathios D, Ruzevick J, Jackson C, Xu H, Shah S, Taube J, Burger P, Quinones-Hinojosa A, Pardoll A, Lim M. PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment. J Neurooncol. 2014 Oct 28. PMID: 25349132.
  21. Salmasi V, Schiavi A, Binder Z, Ruzevick, J, Orr B, Burger P, Ball D, Blitz A, Koch W, Ishii M, Gallia G. Intraoperative hypertensive crisis due to a catecholamine-secreting esthesioneuroblastoma. Head Neck. 2014 Oct 28. PMID: 25352487.
  22. Ruzevick J, Raza S, Recinos P, Chaichana K, Pradilla G, Kim J, Olivi A, Weingart J, Evans J, Quinones-Hinojosa A, Lim M. Technical Note: Orbitozygomatic craniotomy using an ultrasonic osteotome for precise osteotomies. Clinical Neurology and Neurosurgery. 2015 Apr 13; 134: 24-27. PMID: 25935127.
  23. Theodros D, Patel M, Ruzevick J, Bettegowda C. Pituitary adenomas: historical perspective, surgical management, and future directions. CNS Oncology; 2015;4(6): 411-429. PMID: 26497533.
  24. Jackson C, Ceccato C, Nirschl C, Durham N, Ruzevick J, Alme A, Francica B, Yingling J, Dubensky T, Lauer P, Brockstedt D, Baxi E, Calabresi P, Pardo-Villamizar C, Brem H, Pardoll D, Lim M, Drake C. Systemic tolerance mediated by CNS tumors is reversed by combined radiotherapy and vaccination. Clinical Cancer Research, 2016 Mar 1; 22(5): 1161-72. PMID: 26490306.
  25. Kim E, Kim J, Patel M, Mangraviti A, Ruzevick J, Lim M. Immune checkpoint modulators: an emerging anticancer armamentarium. Journal of Immunology Research; 2016; 2016:4683607. PMID: 26881264.
  26. Ruzevick J, Koh EK, Gonzalez-Cuyar L, Cimino P, Moe K, Wright L, Failor R, Ferreira M. Clival paragangliomas: a report of two cases involving the midline skull base and review of the literature. J Neuro-oncol. 2017 May 132(3): 473-478. PMID: 28299533
  27. Mrugala M, Ruzevick J, Zlomanczuk P, Lukas R. Tumor treating fields in neuro-oncological practice. Curr Oncol Rep. 2017 Aug; 19(8) 53 PMID: 28664468
  28. Sen R, White-Dzuro G, Ruzevick J, Kim C, Witt J, Telfeian A, Wang M, Hofstetter C. Intra- and peri-operative complications associated with endoscopic spine surgery: a multi-institutional study. World Neurosurg. 2018 Sept; S1878-8750(18)32029-1 PMID: 30213674
  29. Williams J, Buckley R, Oushy S, Ruzevick J, Chesnut RM. Reversible, position-dependent midbrain compression in a patient with spontaneous intracranial hypotension. World Neurosurg. 2019 Jul 16; 130: 293-297. PMID: 31323415
  30. Nazem A, Ruzevick J, Ferreira M. Advances in meningioma genomics, proteomics, and epigenetics: insights into biomarker identification and targeted therapies. Oncotarget. 2020;11(49): 4544-53. PMID: 33346248
  31. Ruzevick J, Gibson A, Emerson S, Ferreira M.WHO grade III meningiomas: de novo tumors show improved progression free survival and a trend towards improved overall survival as compared to secondary progressive tumors. Journal of Clinical Neuroscience. 2021 Sep;91:105-109. PMID: 34373013
  32. Zhao T, Siu IM, Williamson T, Zhang H, Ji C, Burger P, Connis N, Ruzevick J, Xia M, Cottone L, Flanagan A, Hann C, Gallia G. AZD8055 enhances in vivo efficacy of afatinib in chordomas. Journal of Pathology. 2021 Sep;255(1)72-883. PMID: 34124783
  33. Pangal D, Cote D, Ruzevick J, Yarovinsky B, Kugener G, Wrobel B, Ference E, Swanson M, Hung A, Donoho D, Gianotta S, Zada G. Robotic and robot-assisted skull base neurosurgery: systematic review of current applications and future directions. Neurosurg Focus. 2022 Jan 52; (1)E15. PMID: 34973668
  34. Cardinal T, Pangal D, Strickland B, Newton P, Mahmoodifar S, Mason J, Craig D, Simon T, Tew B, Yu M, Yang W, Chang E, Cabeen R, Ruzevick J, Toga A, Neman J, Salhia B, Zada G. Anatomical and topographical variations in the distribution of brain metastases based on primary cancer origin and molecular subtypes: a systematic review. Neurooncol Adv 2021 Nov 18;4(1)vdab170. PMID: 35024611
  35. Parada C, El-Ghazali F, Toglia D, Ruzevick J, McAvoy M, Emerson S, Karasozen Y, Busald T, Nazem A, Suranowitz S, Shalhub S, Marshall D, Gonzalez-Cuyar L, Dorschner M, Ferreira M. Somatic Mosaicism of a PDGFRB Activating Variant in Aneurysms of the Intracranial, Coronary, Aortic, and Radial Artery Vascular Beds. Journal of the American Heart Association. 2022 Feb 15;11(4)e024289. PMID: 35156398
  36. Shahrestani S, Brown N, Nasrollahi T, Strickland B, Bakhsheshian J, Ruzevick J, Bove I, Lee A, Emeh U, Carmichael J, Zada G. Evaluating the predictive value of comorbidity indices in pituitary surgery: a mixed-effects modeling study using the Nationwide Readmissions Database. Journal of Neurosurgery. 2022 March 18:1-9. PMID: 35303700
  37. Strickland B, Wedemeyer M, Ruzevick J, Micko A, Shahrestani S, Daneshmand S, Shiroishi M, Hwang D, Attenello F, Chen T, Zada G. 5-Aminolevulinic acid enhances fluorescence guided treatment of high grade glioma using angled endoscopic blue light visualization: technical case series with preliminary follow-up. Journal of Neurosurgery. 2022 March 18: 1-9. PMID: 35303704
  38. Pangal D, Wishart D, Shiroishi M, Ruzevick J, Carmichael J, Zada G. Growth hormone secreting pituitary adenomas show distinct extracellular extension patterns compared to nonfunctional pituitary adenomas. Pituitary. 2022 Jun; 25(3): 480-485. PMID: 35334028
  39. Cote D, Ruzevick J, Kang K, Pangal D, Bove I, Carmichael J, Shiroishi M, Strickland B, Zada G. Association between socioeconomic status and presenting characteristics and extent of disease in patients with surgically resected non-functioning pituitary adenoma. Journal of Neurosurgery. 2022 Apr 8:1-8. PMID: 35334028
  40. Shahrestani S, Brown N, Strickland B, Bakhsheshian J, Ghodsi S, Nasrollahi T, Borrelli M, Gendreau J, Ruzevick J, Zada G. The role of frailty in the clinical management  of neurofibromatosis type 1: a mixed-effects modeling study using the Nationwide Readmissions Database. Neurosurgery Focus. 2022 May;52(5): E3. PMID: 35535825


Other publications

1.    Wolf A, Batra S, Bortoletto P, Ruzevick J, Bettegowda C, Coy S, Amendola B, Blach L, Kleinberg L, Rigamonti D. Stereotactic radiosurgery in treatment of cerebral metastases: histological differences in predictors of survival. Cureus.com. Published January 24, 2013.

2.    Patel M, Ruzevick J, Lim M. Management of cerebral brain metastases. Curr Surg Rep. 2014 Oct; 2(74).

3.    Patel MA, Kim JE, Ruzevick J, Lim M. Present and future of immune checkpoint blockade: Monotherapy to adjuvant approaches. World J Immunol 2015 Mar 15; 5(1): 1-15.

4.    Ruzevick J, Wagner T, Hofstetter C. Periprostetic osteolysis after 2 level cervical disc arthroplasty featuring artificial nucleus. Journal of Spine.

5.    Ruzevick J, Strickland B, Zada G. Commentary: Machine vision for real-time intraoperative anatomical guidance: A proof-of-concept study in endoscopic pituitary surgery. Operative Neurosurgery. 2021 June 15:opab203. PMID: 34131741

6.    Ruzevick J and Ellenbogen R. Commentary: A crowdsourced consensus on supratotal resection versus gross total resection for anatomically distinct primary glioblastoma. Neurosurgery. 2021 Oct 13;89(5):E266. PMID: 34467997

7.    Strickland B, Ruzevick J, Zada G. Commentary: Early experience with virtual and synchronized augmented reality platform for preoperative planning and intraoperative navigation: a case series. Operative neurosurgery. 2021 June 25:opab204. PMID: 34171913

8.    Cote D, Ruzevick J, Strickland B, Zada G. Commentary: Hybrid robotics for endoscopic transnasal skull base surgery: singe-centre case series. 2021 Oct 11:opab367. PMID: 34634121

9.    Ruzevick J, Strickland B, Zada G. Commentary: 3-dimensionally printed surgical simulation tool for brain mapping training and preoperative planning. Operative Neurosurgery. 2022 Jan 1;22(1):e70. PMID: 34982929.

10. Ruzevick J, Strickland B, Cote D, Zada G. Commentary: comparison between conventional flash and off-response intraoperative visual evoked monitoring for endoscopic endonasal surgery. Operative Neurosurgery. 2022 Jan 1;22(1):e71-e72. PMID: 34982930

11. Cote D, Ruzevick J, Strickland B, Zada G. Commentary: Development of a new image-guided neuronavigation system: mixed-reality projection mapping is accurate and feasible. Operative Neurosurgery. Operative Neurosurgery. 2022 Feb 1;22(2):e100. PMID 35007267

12. Cote D, Ruzevick J, Strickland B, Zada G. Commentary: Qlone: a simple method to create 36-degree photogrammetry-based 3D model of cadaveric specimens. Operative Neurosurgery. 2022 Feb 1;22(2):e101. PMID: 35007211

13. Strickland B, Attenello F, Ruzevick J, Cote D, Zada G. Commentary: Robotic-assisted digital exoscope for resection of cerebral metastases: a case series. Operative Neurosurgery. 2022 Feb 11 PMID: 35147590

Book Chapters

  1. Ruzevick J, Lim M. Technology and techniques of cranial radiation. Handbook of Radiosurgery in CNS Disease. Eds. M Lim, W Hsu, D Rigamonti, and L Kleinberg. New York, NY: Demos Medical Publishing, Chapter 2: 13 – 25, 2013.
  2. Ruzevick J, Batra S, Rigamonti D. Radiosurgery for vestibular schwannomas. Handbook of Radiosurgery in CNS Disease. Eds. M Lim, W Hsu, D Rigamonti, and L Kleinberg. New York, NY: Demos Medical Publishing, Chapter 5: 83 – 91, 2013.
  3. Ruzevick J and Kleinberg L. Imaging changes following radiosurgery for metastatic intracranial tumors: a review of differentiating radiation effects from tumor recurrence. Handbook of Radiosurgery in CNS Disease. Eds. M Lim, W Hsu, D Rigamonti, and L Kleinberg. New York, NY: Demos Medical Publishing, Chapter 6: 111 – 120, 2013.
  4. Ruzevick J, Batra S, Lim M, Rigamonti D. Radiosurgery for arteriovenous malformations. Handbook of Radiosurgery in CNS Disease. Eds. M Lim, W Hsu, D Rigamonti, and L Kleinberg. New York, NY: Demos Medical Publishing, Chapter 7: 123 – 135, 2013.
  5. Ruzevick J, Raza S, Quinones-Hinojosa A. The role of surgery in the management of skull base chordomas. Controversies in Neuro-Oncology. Eds. A Quinones-Hinojosa and S Raza. New York, NY: Thieme Medical Publishing, Chapter 45: 433-441, 2013.
  6. Ruzevick J and Mrugala M. Alternating electric fields in clinical practice. Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications. Ed. E Wong. New York, NY: Springer Publishing.
  7. Ruzevick J, White-Dzuro G, Kim L, Levitt M, Ferreira M. Intracranial arteriovenous malformations. Management of Head and Neck Vascular Abnormalities. Ed: J Perkins and K Balakrishnan. New York, NY: Springer Publishing.
  8. Ruzevick J and Ferreira M. Torcula meningioma. Skull base tumor: approach strategies. Ed: W Jean. New York, NY: Thieme Publishing.