Dr. Parada is an Assistant Professor of Neurological Surgery and member of the recently formed Fred Hutchinson Cancer Center. She has demonstrated the importance of kinase dysregulation in aggressive meningiomas, highlighting the potential use of kinase inhibitors to treat tumors that fail conventional treatment. Dr. Parada also identified a prognostic biomarker that can distinguish a subgroup of benign meningiomas (grade 1.5) that unexpectedly display an aggressive behavior and requires rapid clinical management. This novel biomarker is currently under prospective trial for clinical implementation at University of Washington Medical Center in Seattle, WA. In the vascular field, she has actively contributed to the identification of key molecules that can be successfully targeted by already FDA-approved drugs, suggesting drug repurposing for a safer and more efficient treatment options. Currently, she is focusing on the implementation of a platform for cancer personalized therapy based on Artificial Intelligence.
Bringing precision medicine into clinics
MMA
- PARADA CA, EL-GHAZALI FM, TOGLIA D, RUZEVICK J, MCAVOY M, EMERSON S, KARASOZEN Y, BUSALD T, NAZEM AA, SURANOWITZ SM, SHALHUB S, MARSHALL DA, GONZALEZ-CUYAR LF, DORSCHNER MO, FERREIRA M JR. Somatic Mosaicism of a PDGFRB Activating Variant in Aneurysms of the Intracranial, Coronary, Aortic, and Radial Artery Vascular Beds. J Am Heart Assoc. 11(4):e024289. 2022 PMID: 35156398
- PARADA CA, DE OLIVEIRA IP, GEWEHR MCF, MACHADO-NETO JA, LIMA K, EICHLER RAS, LOPES LR, BECHARA LRG, FERREIRA JCB, FESTUCCIA WT, CENSONI L, TERSARIOL ILS, FERRO ES. Effect of FKBP12-Derived Intracellular Peptides on Rapamycin-Induced FKBP-FRB Interaction and Autophagy. Cells. 11(3):385, 2022. PMID: 35159195
- SAKAYA G, PARADA CA, EICHLER RA, YAMAKI VN, NAVON A, HEIMANN AS, FIGUEIREDO, EG, FERRO ES. Peptidomic profiling of cerebrospinal fluid from patients with intracranial saccular aneurysms. Journal of Proteomics. 240:104188, 2021. PMID: 33781962
- PARADA CA, OSBUN J, BUSALD T, KARASOZEN Y, KAUR S, SHI M, BARBER J, ADIDHARMA W, CIMINO P, PAN C, GONZALEZ-CUYAR LF, ROSTOMILY R, BORN D, ZHANG J, FERREIRA M. Phosphoproteomic and Kinomic Signature of Clinically Aggressive Grade I (1.5) Meningiomas Reveals RB1 Signaling as a Novel Mediator and Biomarker. Clinical Cancer Research. 26:193 - 05, 2020. PMID: 31615938
- KARASOZEN Y, OSBUN J, PARADA CA, BUSALD T, TATMAN P, GONZALEZ-CUYAR LF, HALE C, ALCANTARA D, O’DRISCOLL M, DOBYNS W, MURRAY M, KIM L, BYERS P, DORSCHNER MO, FERREIRA M. Somatic PDGFRB Activating Variants in Fusiform Cerebral Aneurysms. American Journal of Human Genetics. 104:968 - 76, 2019. PMID: 31031011
- PARADA CA, OSBUN J, KAUR S, YAKKIOUI Y, SHI M, PAN C, BUSALD T, KARASOZEN Y, GONZALEZ-CUYAR L, ROSTOMILY R, ZHANG J, FERREIRA JR M. Kinome and phosphoproteome of high-grade meningiomas reveal AKAP12 as a central regulator of aggressiveness and its possible role in progression. Scientific Reports, 8:2098, 2018. PMID: 29391485
- OSBUN J, TATMAN PD, KAUR S., PARADA CA, BUSALD T, GONZALEZ-CUYAR L, SHI M, BORN D, ZHANG J, FERREIRA JR M. Comparative Proteomic Profiling Using Two- Dimensional Gel Electrophoresis and Identification via LC-MS/MS Reveals Novel Protein Biomarkers to Identify Aggressive Subtypes of WHO Grade I Meningioma. J Neurol Surg B, 78:371-379. 2017. PMID: 28875114
- TATMAN PD, OSBUN J, YAKKIOUI Y, KAUR S, PARADA CA, BUSALD T, BORN D, AHMAD O, ZHANG J, FERREIRA M. Kinase activity in recurring primary Skull Base Chordomas and Chondrosarcomas: identification of novel pathways of oncogenesis and potential drug targets. World Neurosurgery, 107:75-81, 2017. PMID: 28647652
- MIKHEEV A, MIKHEEVA S, TRISTER A, TOKITA M, PARADA CA, BORN D, CARNEMOLLA B, OXFORD R, KOSAI Y, TOZER-FINK K, MANNING T, SILBER J, ROSTOMILY R. Periostin is a novel therapeutic target that predicts and regulates glioma malignancy. Neuro-Oncology. 17(3), 372–382, 2015. PMID: 25140038
- PARADA CA, PORTARO F, MARENGO EB, KLITZKE CF, VICENTE EJ, FARIA M, SANT’ANNA OA, FERNANDES BL. Autolytic Mycobacterium leprae Hsp65 fragments may act to biological markers. Microbial Pathogenesis. v.51, p.268-276, 2011. PMID: 21699972