The Injustices of the Social Security System With Regard to Psychiatric Patients
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UW Neurological Surgery Recent PubMed Publications
Machine Learning Analysis of the Cerebrovascular Thrombi Lipidome in Acute Ischemic Stroke
OBJECTIVE: The aim of this study was to identify a signature lipid profile from cerebral thrombi in acute ischemic stroke (AIS) patients at the time of ictus. METHODS: We performed untargeted lipidomics analysis using liquid chromatography-mass spectrometry on cerebral thrombi taken from a nonprobability, convenience sampling of adult subjects (≥18 years old, n = 5) who underwent thrombectomy for acute cerebrovascular occlusion. The data were classified using random forest, a machine learning...
The role of increasing pharmacy and community distributed naloxone in the opioid overdose epidemic in Massachusetts, Rhode Island, and New York City
CONCLUSION: Naloxone distribution volumes were correlated with fatal opioid overdose, suggesting medication was getting to communities where it was needed most. Amid high rates of overdose driven by fentanyl in the drug supply, our findings suggest additional prevention, treatment, and harm reduction interventions are required-and dramatically higher naloxone volumes needed-to reverse the opioid overdose crisis in the US.
Hsp90β inhibition upregulates interferon response and enhances immune checkpoint blockade therapy in murine tumors
Response resistance to the immune checkpoint blockade (ICB) immunotherapy remains a major clinical challenge that may be overcome through the rational combination of ICB and specific targeted therapeutics. One emerging combination strategy is based on sensitizing ICB-refractory tumors with antagonists of 90kD heat shock protein (Hsp90) that target all four isoforms. However, pan-Hsp90 inhibitors are limited by the modest efficacy, on-target and off-tumor toxicities, and induction of the heat...
Comparative spatially explicit approach for testing effects of soil chemicals on terrestrial wildlife bioindicator demographics
Wildlife species are often used as bioindicators to evaluate the extent and severity of environmental contamination and the effectiveness of remediation practices. A common approach for investigating population- or community-level impacts on bioindicators compares demographic parameter estimates (e.g., population size or density) between sites that were subjected to different levels of contamination. However, the traditional analytical method used in such studies is nonspatial capture-recapture,...
Creation and preclinical evaluation of genetically attenuated malaria parasites arresting growth late in the liver
Whole-sporozoite (WSp) malaria vaccines induce protective immune responses in animal malaria models and in humans. A recent clinical trial with a WSp vaccine comprising genetically attenuated parasites (GAP) which arrest growth early in the liver (PfSPZ-GA1), showed that GAPs can be safely administered to humans and immunogenicity is comparable to radiation-attenuated PfSPZ Vaccine. GAPs that arrest late in the liver stage (LA-GAP) have potential for increased potency as shown in rodent malaria...
Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative
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Kidney biopsy in lupus nephritis after achieving clinical renal remission: paving the way for renal outcome assessment
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BosR: A novel biofilm-specific regulator in <em>Pseudomonas aeruginosa</em>
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Organoid Technologies for SARS-CoV-2 Research
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Evaluating equity in community-based naloxone access among racial/ethnic groups in Massachusetts
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Comparisons of quantitative approaches for assessing microglial morphology reveal inconsistencies, ecological fallacy, and a need for standardization
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Association between jail-based methadone or buprenorphine treatment for opioid use disorder and overdose mortality after release from New York City jails 2011-17
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Ferret acute lung injury model induced by repeated nebulized lipopolysaccharide administration
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Oxysterol misbalance critically contributes to Wilson disease pathogenesis
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Intraventricular B7-H3 CAR T cells for diffuse intrinsic pontine glioma: preliminary first-in-human bioactivity and safety
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Natural language processing for identification of hypertrophic cardiomyopathy patients from cardiac magnetic resonance reports
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Reactive morphology of dividing microglia following kainic acid administration
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Full Endoscopic Repair of Spontaneous Ventral Cerebrospinal Fluid Leaks in the Spine: Systematic Review of Surgical Treatment Options and Illustrative Case
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A transcriptomic analysis of the effects of macrophage polarization and endotoxin tolerance on the response to Salmonella
Salmonella is an intracellular pathogen causing significant morbidity and mortality. Its ability to grow inside macrophages is important to virulence, and is dependent on the activation state of the macrophages. Classically activated M1 macrophages are non-permissive for Salmonella growth, while alternatively activated M2 macrophages are permissive for Salmonella growth. Here we showed that endotoxin-primed macrophages (MEP), such as those associated with sepsis, showed similar levels of...
"university of washington"[affiliation] and neurological surge...: Latest results from PubMed
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