Previously acquired knowledge provides a structure, or schema, that shapes ongoing experience and facilitates the rapid acquisition of new information. A large body of research supports the idea that interactions between the hippocampus and neocortex are critical for rapid learning based on prior knowledge; however, there is a surprising gap in our understanding regarding cortical-hippocampal interactions in the primate brain. Here, in parallel studies in monkeys and humans, we propose to take advantage of newly available large-scale recording techniques to examine hippocampal-neocortical interaction that may underlie both the development of a schema and the use of a schema for rapid learning. Read more here.
Jeffrey G. Ojemann, MD (Site PI)
Sponsor: Mayo Clinic Rochester and NIH/NIMH