Chronic Effects of Neurotrauma Consortium (CENC)

Study 2. Innovative Telehealth Interventions for mTBI

I. Research Plan

The overall goal of Study 2 is to develop feasible, cost-effective, manualized telehealth interventions to enhance resilience, coping, and management of the physical, psychological, and cognitive sequelae in individuals with combat-related mTBI that are accessible across a wide array of settings. An effective approach for these conditions in Veterans with mTBI could positively influence outcomes for the large number of individuals who sustain neurotrauma and are, as a result, at increased risk for both disabling sequelae throughout their lifetime and potentially neurodegeneration. The overall goal for the project is to obtain the necessary information to provide a highly effective and sustainable resource.

Specific Aims

Aim 1: Develop Telehealth interventions that will:

1.A Provide education and strategies that will enhance resilience and ameliorate mTBI-related symptoms.

1.B Enhance engagement in longitudinal data collection.

Aim 2: Conduct a three-arm randomized controlled trial of up to 900 Veterans to:

2.A Compare the effectiveness of Telehealth, Enhanced Telehealth, and Usual Care in improving mTBI comorbidity domains (psychological distress, pain, insomnia, and cognitive functioning), postconcussive symptoms, and quality of life.

2.B Examine potential mediators of intervention efficacy (resilience, self-efficacy, working alliance, social support).

2.C Examine potential moderators of intervention efficacy, such as demographic (racial and ethnic, socioeconomic), TBI-related factors ( time since injury, number of known mTBIs), psychological factors (history of depression, PTSD, substance abuse), and cognitive deficits.

Principal Investigator(s)