Assessment of RNA Expression of Adhesion Molecules, Mechanoreceptors, and Inflammatory Proteins in Endothelial Cells Harvested From Unruptured Intracranial Aneurysms in Adults

The pathophysiology of intracranial aneurysms is multifactorial. Notwithstanding the past research efforts which mostly focused on the role of inflammation in aneurysm development, several questions remain unanswered regarding the role of mechanoreceptors and adhesion molecules in the development and evolution of intracranial aneurysms. The goal of this study is to assess the changes in inflammatory and adhesion molecules as well as mechanoreceptors of endothelial cells of unruptured intracranial aneurysms. The results can shed more light on the pathophysiology of aneurysm development and evolution. In addition, to create an RNA expression profiles catalog which can be used for comparison between aneurysmal and normal endothelial cells.

Principal Investigator(s)
Award Info

The Aneurysm and AVM Foundation (TAAF)