Outcome pRognostication of Acute brain injury with the NeuroloGical pupil indEx – ORANGE

The primary aim is to evaluate the association between abnormal Neurological Pupil index (NPi) and long-term outcome (6-month mortality and neurological recovery, measured with the extended Glasgow Outcome Score, GOS-E) in patients with acute traumatic and haemorrhagic acute brain injury (ABI).
The secondary aim, in patients with ICP monitoring, is to evaluate the relationship of abnormal NPi and intracranial pressure following acute traumatic and haemorrhagic ABI.