David J. Bonda, MD

Headshot - David J. Bonda, MD
Job Title
Acting Instructor
Biography

Dr. Bonda was born in New York, NY and grew up in Cleveland, Ohio. He earned his bachelor’s degree in neuroscience from the University of Pennsylvania and his medical degree from Case Western Reserve University School of Medicine. He completed seven years of neurosurgical training in the Department of Neurosurgery at the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, during which time he spent two years doing basic neuroscience research at Cold Spring Harbor Laboratory in Long Island, New York. David has subsequently moved to Seattle for a pediatric neurosurgery fellowship at Seattle Children’s Hospital.

Clinical Interest

Pediatric epilepsy surgery, pediatric functional neurosurgery, pediatric oncology

Research Interests

Understanding the neural circuitry governing the control of reflexive behavior; mapping epilepsy circuits for improved targeted neuromodulation therapies

Education

Medical Education: Case Western Reserve University School of Medicine

Residency: Donald and Barbara Zucker School of Medicine at Hofstra/Northwell Health

Publications

Publications:

P1.         Bonda D., Silverstein J.W., Katz J., Ellis, J.A., Boockvar, J., D’Amico, R., Asleep Speech Mapping Using Orofacial Muscles as Surrogates for Motor Speech in Patients Who Cannot Tolerate Awake Surgery: A Case Series. Cureus 13(6): e15861. doi:10.7759/cureus.15861

P2.         Bonda, D., Pruitt, R., Theroux, L., Goldstein, T., Stefanov, D., Kothare, S., Karkare, S., Rodgers, S. Robot-assisted stereoelectroencephalography electrode placement in twenty-three pediatric patients: a high-resolution analysis of individual lead placement time and accuracy at a single institution. Childs Nerv Syst. 2021 Mar 18.

P3.         Pruitt, R., Bonda, D., Goldstein, T., Kothare, S., Karkare, S., Rodgers, S. Laser Interstitial Thermal Therapy for Gyrus Rectus Cortical Dysplasia in a Child: A Technical Note. Childs Nerv Syst. 2021 Apr 7

P4.         Einstein, E., Bonda, D., D’Amico, R. Multiple brain abscesses due to Nocardia otitidiscaviarum: Case report and treatment implications. Cureus 13(4): e14362, 2021

P5.         Einstein, E., Bonda, D., Hosseini, H., Harel, A., Palmer, J., Giglio, P., Barve, R., Gould, M., Lonser, R., D’Amico, R. Large Adult Spinal Diffuse Midline Histone H3 Lysine27-to-Methionine-Mutant Glioma With Intramedullary and Extramedullary Components Presenting With Progressive Hydrocephalus: A Case Report Highlighting Unique Imaging Findings and Treatment. Cureus 13(5): e15333, 2021

P6.         Bonda, D., Pruitt, R., Goldstein, T., Varghese, A., Shah, A., Rodgers, S. ROSA rehearsal: combining 3D-printing technology with preoperative stereotactic planning for placement of stereoencephalography electrodes. Oper Neurosurg (ePub ahead of print); 2019

P7.         Bonda, D., Pruitt, R., Goldstein, T., Varghese, A., Mittler, M., Schneider, S., Rodgers, S. ROSA rehearsal: using 3D printing technology to facilitate the introduction of stereotactic robotic neurosurgical equipment. Oper Neurosurg; 2019 Oct (ePub ahead of print)

P8.         Bonda, D.J., Labib, M., Katz, J., Ortiz, R.A., Chalif, D., Setton, A., Langer, D., Dehdashti, A.; Intracranial Bypass of Posterior Inferior Cerebellar Artery Aneurysms: Indications, Technical Aspects, and Clinical Outcomes. Oper Neurosurg (Hagerstown) 2017

P9.         Bonda D.J., Stone JG, Torres SL, Siedlak SL, Perry G, Kryscio R, Jicha G, Casadesus G, Smith MA, Zhu X, Lee HG. Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance. J Neurochem. 2014 Jan;128(1):162-72.

P10.      Bonda, D.J., Mailankot, M., Stone, J.G., Garrett, M.R., Staniszewska, M., Castellani, R.J., Siedlak, S.L., Zhu, X., Lee, H.G., Perry, G., Nagaraj, R.H. and Smith, M.A. (2010) Indoleamine 2,3-dioxygenase and 3-hydroxy-kynurenine modifications are found in the neuropathology of Alzheimer’s disease. Redox Rep., 15, 161-168. PMCID: PMC2956440

P11.      Bonda, D.J., Evans, T.A., Santocanale, C., Llośa, J.C., Viña, J., Bajic, V.P., Castellani, R.J., Siedlak, S.L., Perry, G., Smith, M.A. and Lee, H.G. (2009) Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. AGING1, 382-388.

P12.     Bajić, V., Spremo-Potparević, B., Zivković, L., Bonda, D.J., Siedlak, S.L., Casadesus, G., Lee, H.G. and Smith, M.A. (2009) The X-chromosome instability phenotype in Alzheimer’s disease: a clinical sign of accelerating aging? Med. Hypotheses73, 917-920.

P13.      Gustaw, K., Siedlak, S.L., Bonda, D.J., Lerner, A.L., Tabaton, M., Garrett, M., Kumar, S., Perry, G. and Smith, M.A. (2010) Dissociated amyloid-β antibody levels as a serum biomarker for the progression of Alzheimer’s disease: a population-based study. Exp. Gerontol.45, 47-52.

P14.      Thakur, A., Siedlak, S.L., James, S.L., Bonda, D.J., Rao, A., Webber, K.M., Camins, A., Pallàs, M., Casadesus, G., Lee, H.G., Bowser, R., Raina, A.K., Perry, G., Smith, M.A. and Zhu, X. (2008) Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease. Int. J. Clin. Exp. Pathol.1, 134-146.

P15.      Bonda, D.J., Webber, K.M., Siedlak, S.L., Perry, G., Friedland, R.P. and Smith, M.A. (2007) The pathology of Alzheimer disease elicits an in vivo immunological response. Am. J. Immunol.3, 10-14.

 

C1.        Tabor, J., Bonda, D., LeMonda, B., D’Amico, R. Neuropsychiatric outcomes following supratotal resection for high-grade glioma: A review. J Neurooncol. 2021 Mar 21

C2.        Bonda DJ, Manjila S, Mehndiratta P, Khan F, Miller BR, Onwuzulike K, Puoti G, Cohen ML, Schonberger LB, Cali I. (2016) Human prion diseases: surgical lessons learned from iatrogenic prion transmission. Neurosurg Focus. 2016 Jul;41(1)

C3.        Bonda D.J., Manjila, S., Selman, W.R., Dean, D. (2015) The Recent Revolution in the Design and Manufacture of Cranial Implants: Modern Advancements and Future Directions. Neurosurgery. 2015 Nov;77(5):814-24

C4.        Bonda, D.J., Lee, H.G., Perry, G., Castellani, R.C., Zhu, X. and Smith, M.A. (2011) Neuronal failure in Alzheimer disease: a view through the oxidative stress looking-glass. Neurosci Bull. 2014 Apr;30(2):243-52

C5.        Bonda, D.J., Lee, H.G., Camins, A., Pallàs, M., Casadesus, G., Smith, M.A. and Zhu, X. (2011) The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations. Lancet Neurol., 10, 275-279. PMCID: PMC3163839

C6.        Bonda, D.J., Lee, H.G., Blair, J.A., Zhu, X., Perry, G. and Smith, M.A. (2011) Role of metal dyshomeostasis in Alzheimer’s disease. Metallomics, 3, 267-270. PMCID: PMC3117398

C7.        Bonda, D.J., Castellani, R.J., Zhu, X., Nunomura, A., Lee, H.G., Perry, G. and Smith, M.A. (2011) A novel perspective on tau in Alzheimer’s disease. Curr. Alzheimer Res., 8, 639-642

C8.        Bonda, D.J., Liu, G., Men, P., Perry, G., Zhu, X. and Smith, M.A. (2011) Nanoparticle delivery of transition-metal chelators to the brain: oxidative stress will never see it coming! In Progress in Brain Research, Vol. 185, Nanoneuroscience and Nanoneuropharmacology, Sharma, H.S. (Ed.), Elsevier B.V., Amsterdam, in press.

C9.        Bonda, D.J., Smith, M.A., Perry, G., Lee, H.G., Wang, X. and Zhu, X. (2011) The mitochondrial dynamics of Alzheimer’s disease and Parkinson’s disease offer important opportunities for therapeutic intervention. Curr. Pharm. Des., 2011 Sep 9. 17, 3374-3380. PMID: 21902671

C10.     Bonda, D.J., Castellani, R.J., Lee, H.G., Tabaton, M., Casadesus, G., Perry, G., Zhu, X., and Smith, M.A. (2010) Down syndrome and Alzheimer disease: a “multi-hit” hypothesis based on multiple contributing factors resulting in pleotrophic consequences. In Handbook of Down Syndrome Research, Jelinek, D. and Dvorak, G. (Eds.). Nova Science Publishers.

C11.     Rodrigues, R., Bonda, D.J., Perry, G., Castellani, R.J., Casadesus, G., Lee, H.G., Lee, H.P., Wang, X., Zhu, X., Petersen, R.B. and Smith, M.A. (2010) Oxidative stress and neurodegeneration: an inevitable consequence of aging? Implications for therapy. In Brain Protection in Neuropsychiatric Disorders: From Concept and Mechanisms to Clinical Practice, Ritsner, M. (Ed.). Springer, 2010, 305-323

C12.     Bonda, D.J., Wang, X., Perry, G., Smith, M.A. and Zhu, X. (2010) Mitochondrial dynamics in Alzheimer disease: opportunities for future treatment strategies. Drugs Aging, 2010 27, 181-92 PMCID: PMC2923854

C13.     Gustaw-Rothenberg, K., Lerner, A., Bonda, D.J., Lee, H.G., Zhu, X., Perry, G. and Smith, M.A. (2010) Biomarkers in Alzheimer disease: past, present, and future. Biomarkers Med., in press.

C14.     Bonda, D.J., Bajic, V.P., Spremo-Potparevic, B., Casadesus, G., Zhu, X., Smith, M.A. and Lee, H.G. (2010) Cell cycle aberrations and neurodegeneration: a review. Neuropathol. Appl. Neurobiol.,36, 157-163

C15.     Bonda, D.J., Wang, X., Gustaw-Rothenberg, K.A., Perry, G., Smith, M.A. and Zhu, X. (2010) Mitochondrial drugs for Alzheimer disease. Pharmaceuticals, 23, 287-298 PMCID: PMC2909133

C16.     Bonda, D.J., Wang, X., Perry, G., Nunomura, A., Tabaton, M., Zhu, X. and Smith, M.A. (2010) Oxidative stress in Alzheimer disease: a possibility for prevention. Neuropharmacology, 59, 290-294. Epub 2010 Apr 13.

C17.     Bonda, D.J., Lee, H.P., Lee, H., Perry, G., Zhu, X. and Smith, M.A. (2010) Novel therapeutics for Alzheimer disease: an update. Curr. Opin. Drug Discov. Devel., 13, 235-246. PMCID: PMC2931269

C18.     Bonda, D.J., Lee, H.P., Kudo, W., Zhu, X., Smith, M.A. and Lee, H.G. (2010) Pathological implications of cell cycle re-entry in Alzheimer disease. Expert Rev. Mol. Med.12, e19. PMCID: PMC2922901

C19.     Su, B., Wang, X., Bonda, D., Perry, G., Smith, M. and Zhu, X. (2010) Abnormal mitochondrial dynamics—a novel therapeutic target for Alzheimer’s disease? Mol. Neurobiol.41, 87-96. PMCID: PMC3129743

 

Abstracts/Oral Presentations

A1.         Bonda D., Silverstein J.W., Katz J., Ellis, J.A., Boockvar, J., D’Amico, R., Asleep Speech Mapping Using Orofacial Muscle MEPs as Surrogates for Motor Speech in Patients Who Cannot Tolerate Awake Surgery. Oral Presentation, Congress of Neurological Surgeons Tumor Section Meeting, Austin, Texas, October, 2021

A2.         Bonda, D., Pruitt, R., Goldstein, T., Varghese, A., Shah, A., Rodgers, S.  Robotic Rehearsal for Stereoencephalography: Combining 3D-Printing Technology with Preoperative Stereotactic Planning for Placement of Intracranial Depth Electrodes. Poster Presentation, The AANS/CNS Section on Pediatric Neurological Surgery, Scottsdale, AZ. December 2019

A3.         Bonda, D., Pruitt, R., Goldstein, T., Varghese, A., Mittler, M., Schneider, S., Rodgers, S. ROSA rehearsal: using 3D printing technology to facilitate the introduction of stereotactic robotic neurosurgical equipment. Poster Presentation, World Society for Stereotactic and Functional Neurosurgery Annual Meeting, New York, NY. June 2019

A4.         Bonda, D., Pruitt, R., Goldstein, T., Varghese, A., Rodgers, S. ROSA rehearsal II: combining 3D-printing technology with preoperative stereotactic planning for depth electrode placement. Poster Presentation, 12th International Epilepsy Colloquium, Lyon, France. May 2019

A5.         Bonda, D., Carrazco, C., Lehner, K., Katz, J., Chalif, D., Sanelli, P., Dehdashti, A. Aneurysm geometry predicts rupture in very small (<4mm) intracranial aneurysms. Oral presentation at the AANS/CNS CV Section Meeting, Los Angeles, CA. January 2017.

A6.         Kerstetter-Fogel, A., Harris, P., Bonda, D., Barnholtz-Sloan, J., Couce, M., Sloan, A. ROBO2-SLIT1 Signalling implicated in glioma invasion. Poster Presentation, Society for Neurooncology, Miami, FL. November 2014

A7.         Bonda D., Kerstetter-Fogel, A., Harris, P., Sloan, A. Assessment of GBM-derived Stem Cells and Stem Cell Isolates in Hypoxia and Normoxia. Poster Presentation, Lepow Day, Case Western Resreve School of Medicine, Cleveland, OH. May 2013

A8.         Thakur, A., James, S.L., Siedlak, S.L., Raina, A.K., Bonda, D.J., Perry, G., Smith, M.A. and Zhu, X. (2007) Ectopic localization of phospho-retinoblastoma in Alzheimer disease. SOURCE Symposium & Poster Session, 74, Case Western Reserve School of Medicine, Cleveland, OH, 2007.

A9.         Bonda, D.J., Webber, K.M., Siedlak, S.L., Perry, G., Friendland, R.P. and Smith, M.A. (2007) The pathology of Alzheimer disease elicits an in vivo immunological response. 2007 CWRU Summer Program in Undergraduate Research (SPUR), 10.

A10.         Bonda, D., Stone, J., Smith, M.A., Zhu, X., Lee, H.G. and Casadesus, G. (2010) Association of leptin receptor with neurofibrillary tangles of Alzheimer disease. Research ShowCASE 2010, 215.

A11.         Stone, J., Bonda, D., Lee, H.G., Richardson, S., Perry, G., Casadesus, G. and Smith, M. (2010) Association of leptin receptor with neurofibrillary tangles of Alzheimer disease. J. Neuropathol. Exp. Neurol.69, 531.

A12.     Stone, J., Bonda, D., Lee, H.G., Richardson, S., Casadesus, G. and Smith, M.A. (2010) Association of leptin receptor with neurofibrillary tangles of Alzheimer disease. Alzheimers Dement.(Suppl.), S231.